Galectin-3 plays a protective role in Leishmania (Leishmania) amazonensis infection
| Autor: | Luiz Ricardo Goulart, João Paulo Silva Servato, Débora de Oliveira Santos, Marcelo José Barbosa Silva, Samuel Cota Teixeira, Aline Alves da Silva, Claudio Vieira da Silva, Rafael M Oliveira, Marlus Alves dos Santos, Rebecca Tavares e Silva Brígido, Thaise Lara Teixeira, Bruna Cristina Borges, Cassiano C. Rodrigues |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Damp Galectin 3 Leishmaniasis Cutaneous Context (language use) Biology Biochemistry Microbiology 03 medical and health sciences Mice 0302 clinical medicine Cutaneous leishmaniasis medicine Parasite hosting Animals Leishmania Mice Knockout Pattern recognition receptor medicine.disease biology.organism_classification Mice Inbred C57BL 030104 developmental biology Endocytic vesicle Galectin-3 Female 030215 immunology |
| Zdroj: | Glycobiology. 31(10) |
| ISSN: | 1460-2423 |
| Popis: | Leishmania (L.) amazonensis is one of the species responsible for the development of cutaneous leishmaniasis in South America. After entering the vertebrate host, L. (L.) amazonensis invades mainly neutrophils, macrophages and dendritic cells. Studies have shown that gal-3 acts as a pattern recognition receptor. However, the role of this protein in the context of L. (L.) amazonensis infection remains unclear. Here, we investigated the impact of gal-3 expression on experimental infection by L. (L.) amazonensis. Our data showed that gal-3 plays a role in controlling parasite invasion, replication and the formation of endocytic vesicles. Moreover, mice with gal-3 deficiency showed an exacerbated inflammatory response. Taken together, our data shed light to a critical role of gal-3 in the host response to infection by L. (L.) amazonensis. |
| Databáze: | OpenAIRE |
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