Subcortical amyloid relates to cortical morphology in cognitively normal individuals
| Autor: | Maude Joannette, Pénélope Sévigny Dupont, Jim Nikelski, Shady Rahayel, Christian Bocti, Marie Maxime Lavallée, Howard Chertkow, Sven Joubert |
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| Přispěvatelé: | Université de Montréal. Faculté des arts et des sciences. Département de psychologie |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Amyloid Amyloid beta Subcortical Neuropsychological Tests 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound Cognitive aging Cognition 0302 clinical medicine Image Processing Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Pittsburgh compound B Effects of sleep deprivation on cognitive performance Neuropsychological assessment Episodic memory Default mode network Aged Aged 80 and over Brain Mapping biology medicine.diagnostic_test Working memory business.industry Brain General Medicine Magnetic Resonance Imaging chemistry Positron-Emission Tomography 030220 oncology & carcinogenesis biology.protein Female Amyloid-beta business Neuroscience |
| DOI: | 10.1007/s00259-019-04446-w |
| Popis: | Purpose Amyloid (Aβ) brain deposition can occur in cognitively normal individuals and is associated with cortical volume abnormalities. Aβ-related volume changes are inconsistent across studies. Since volume is composed of surface area and thickness, the relative contribution of Aβ deposition on each of these metrics remains to be understood in cognitively normal individuals. Methods A group of 104 cognitively normal individuals underwent neuropsychological assessment, PiB-PET scan, and MRI acquisition. Surface-based cortical analyses were performed to investigate the effects of cortical and subcortical Aβ burden on cortical volume, thickness, and surface area. Mediation analyses were used to study the effect of thickness and surface area on Aβ-associated volume changes. We also investigated the relationships between structural metrics in clusters with abnormal morphology and regions underlying resting-state functional networks and cognitive performance. Results Cortical Aβ was not associated with cortical morphology. Subcortical Aβ burden was associated with changes in cortical volume, thickness, and surface area. Aβ-associated volume changes were driven by cortical surface area with or without thickness but never by thickness alone. Aβ-associated changes overlapped greatly with regions from the default mode network and were associated with lower performance in visuospatial abilities, episodic memory, and working memory. Conclusions In cognitively normal individuals, subcortical Aβ is associated with cortical volume, and this effect was driven by surface area with or without thickness. Aβ-associated cortical changes were found in the default mode network and affected cognitive performance. Our findings demonstrate the importance of studying subcortical Aβ and cortical surface area in normal ageing |
| Databáze: | OpenAIRE |
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