Downloadable computer models for renal replacement therapy
Autor: | Timothy W. Meyer, Jason Walther, Channing R. Robertson, D.W. Bartlett, W. Chew, Thomas H. Hostetter |
---|---|
Rok vydání: | 2006 |
Předmět: |
medicine.medical_specialty
Time Factors Metabolic Clearance Rate medicine.medical_treatment Diffusion 030232 urology & nephrology Ultrafiltration Thermodynamics Dialysate flow 030204 cardiovascular system & hematology Artificial kidney Renal Circulation hemofiltration 03 medical and health sciences 0302 clinical medicine Renal Dialysis Mass transfer medicine Animals Humans Computer Simulation Renal replacement therapy computer Mathematics hemodialysis Mathematical model modeling Membranes Artificial Models Theoretical Hemodialysis Solutions Surgery Renal Replacement Therapy Hematocrit Nephrology Software Production rate Glomerular Filtration Rate |
Zdroj: | Kidney International. 69(6):1056-1063 |
ISSN: | 0085-2538 |
DOI: | 10.1038/sj.ki.5000196 |
Popis: | Mathematical models can predict solute clearances and solute concentrations during renal replacement therapy. At present, however, most nephrologists cannot use these models because they require mathematical software. In this report, we describe models of solute transport by convection and diffusion adapted to run on the commonly available software program Excel® for Macintosh® computers and PCs running Windows®. Two programs have been created that can be downloaded from http://www.stanford.edu/~twmeyer/ or http://dev.satellitehealth.com/research/journal.asp. The first, called ‘Dr Addis Clearance Calculator', calculates clearance values from inputs including the blood flow Q b , the hematocrit, the ultrafiltration rate Q f , the dialysate flow rate Q d , the reflection coefficient σ and the mass transfer area coefficient K o A for the solute of interest, and the free fraction f if the solute is protein bound. Solute concentration profiles along the length of the artificial kidney are displayed graphically. The second program, called ‘Dr Coplon Dialysis Simulator', calculates plasma solute concentrations from the clearance values obtained by the first program and from additional input values including the number of treatments per week, the duration of the treatments, and the solute's production rate and volumes of distribution. The program calculates the time-averaged solute concentration and provides a graphic display of the solute concentration profile through a week-long interval. |
Databáze: | OpenAIRE |
Externí odkaz: |