The stability and potency of vaccines prepared from inactivated foot-and-mouth disease virus concentrates
| Autor: | T.R. Doel, Deborah J. David |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Time Factors
Nitrogen Drug Storage Guinea Pigs Proteolytic degradation Enzyme-Linked Immunosorbent Assay Biology Antibodies Viral Vaccines Attenuated General Biochemistry Genetics and Molecular Biology Virus Microbiology Aphthovirus Drug Stability Neutralization Tests Freezing Centrifugation Density Gradient Potency Animals Centrifugation Vaccination biology.organism_classification Virology Female Foot-and-mouth disease virus |
| Zdroj: | Journal of biological standardization. 12(3) |
| ISSN: | 0092-1157 |
| Popis: | The stability of 146S particles in concentrates of foot-and-mouth disease virus stored at 4 degrees C was similar to that of 146S particles in a conventional virus preparation. Proteolytic degradation of VPl was not observed in the stored conventional virus preparation or inhibitor-supplemented concentrate but was observed in a supplement-free concentrate. The potencies of vaccines made from the conventional and concentrated preparations and stored in parallel at 4 degrees C appeared to decrease after 16 weeks. The vaccines made from the supplement-free concentrate and the Trasylol supplemented concentrate appeared to be at least as potent as the conventional vaccine and were clearly superior to vaccine made from ox serum supplemented concentrate. |
| Databáze: | OpenAIRE |
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