Comparison of cisplatin-induced nephrotoxicity when using conventional versus short hydration in gastric cancer-a retrospective study
| Autor: | Takeshi Aoyama, Takashi Tsunoda, Ryota Furutani, Kazuyoshi Kawakami, Kazuyuki Ito, Kensei Yamaguchi, Hiroki Kato, Kazuo Kobayashi, Takashi Ichimura, Akane Hagino, Masashi Nakamura, Kenichi Suzuki, Hidenori Yoshioka, Toshihiro Hama, Makoto Hiraide |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Magnesium supplementation 030106 microbiology Antineoplastic Agents Nephrotoxicity Body Mass Index 03 medical and health sciences 0302 clinical medicine Cisplatin induced nephrotoxicity Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Pharmacology (medical) Lung cancer Aged Retrospective Studies Pharmacology Cisplatin business.industry Medical record Cancer Retrospective cohort study Acute Kidney Injury Middle Aged medicine.disease Infectious Diseases 030220 oncology & carcinogenesis Fluid Therapy Female business medicine.drug |
| Zdroj: | Journal of chemotherapy (Florence, Italy). 32(3) |
| ISSN: | 1973-9478 |
| Popis: | Although a short hydration protocol for cisplatin has been recently developed for use in lung cancer, this has yet to be established for gastric cancer. This study reviewed medical records of patients with gastric cancer who received XPT(capecitabine/cisplatin/trastuzumab) therapy containing cisplatin. Patients received either the conventional or short hydration regimen. Nephrotoxicity was compared between these two regimens by monitoring the serum creatinine. Out of the 26 total patients, 19 received the conventional regimen while 7 received the short hydration regimen. There was a higher nephrotoxicity was observed in the group receiving the conventional regimen (42.1%, 8/19) as compared to the short hydration regimen (0%, 0/7). There was a statistically significant difference in nephrotoxicity between the regimens ( |
| Databáze: | OpenAIRE |
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