Peculiarities of the functional state of the pituitary-gonadal system of the neuroendocrinal regulation in adolescent girl swith auto immune hepatitis

Autor: N. M. Dyadyushko, E. F. Chaykivska
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Education, Health and Sport, Vol 10, Iss 12, Pp 235-245 (2020)
ISSN: 2391-8306
Popis: Chaykivska E. F., Dyadyushko N. M. Peculiarities of the functional state of the pituitary-gonadal system of the neuroendocrinal regulation in adolescent girl swith auto immune hepatitis. Journal of Education, Health and Sport. 2020;10(12):235-245. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.12.023 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.12.023 https://zenodo.org/record/4445251 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 09.11.2020. Revised: 25.11.2020. Accepted: 28.12.2020. PECULIARITIES OF THE FUNCTIONAL STATE OF THE pituitary-GONADAL SYSTEM OF THE NEUROENDOCRINAL REGULATION IN adolescent GIRL SWITH auto immune hepatitis 1E. F. Chaykivska, 2N. M. Dyadyushko 1Danylo Halytsky Lviv National Medical University, Ukraine; 2Municipal non-profit enterprise "3rd city clinical hospital on Lviv", Ukraine Abstract Girls and women make up 75% of patients with autoimmune hepatitis (AIH). The peak incidence of AIH occurs in childhood, when the disease is called juvenile AIH. The objective: to determine the features of the functional state of the pituitary-gonadal system of neuroendocrine regulation in adolescent girls with AIH. Material and methods. During 2010-2020, 66 girls of the main group AIH, patients with AIH, and 180 conditionally somatically and gynecologically healthy girls of the control group K at the age of 12-17 years were under observation. Comprehensive examination included history taking, assessment of sexual development, clinical and biochemical blood tests, determination of autoantibodies, markers of viral hepatitis, ultrasound examination of the abdominal cavity, liver biopsy (in main group). Peripheral serum hormone levels were determined in certain age groups (12, 13, 14, 15, 16 and 17 years): luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), estradiol (E2), progesterone (P4), free testosterone (fT). Results. Against the background of disorders of morphofunctional properties of the liver in 12-, 13-, 14- 15-, 16- and 17-year-old girls with AIH noted a significant decrease in the score of sexual development in all age groups compared to the same indicator in the relevant age control groups: 3.21 ± 0.40 vs. 4.94 ± 0.37, 3.46 ± 1.00 vs. 7.91 ± 0.58, 7.03 ± 1.44 vs. 11.08 ± 0.25, 7.80 ± 0.65 vs. 11.86, 10.65 ± 0.79 vs. 11.98 points. The average total level of LH in the Group AIHwas 3.77 ± 0.25 against 4.46 ± 0.10 mIU / ml in group K (p Key words: autoimmune hepatitis; morphofunctional properties of the liver; adolescent girls; puberty; sexual development; pituitary-gonadal neuroendocrine regulation.
Databáze: OpenAIRE
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