Roeky Mountain Spotted Fever Vaccine: A Regional Need
| Autor: | David H. Walker, Mario R. Montenegro, Barbara C. Hegarty, Giuseppe R. Tringali |
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| Přispěvatelé: | School of Medicine, Universidade Estadual Paulista (UNESP), Universita di Palermo |
| Jazyk: | angličtina |
| Rok vydání: | 1984 |
| Předmět: |
Male
Protective immunity animal structures Rocky Mountain spotted fever Fulminant Guinea Pigs Rickettsia rickettsii Rocky Mountain spotted fever vaccine Rickettsial Vaccines North Carolina Animals Medicine Rickettsia Rocky Mountain Spotted Fever Vaccines Virulence biology business.industry General Medicine bacterial infections and mycoses biology.organism_classification medicine.disease Virology Spotted fever bacteria Female business |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2022-04-28T19:53:45Z (GMT). No. of bitstreams: 0 Previous issue date: 1984-01-01 Because the killed Rickettsia vaccines have failed to provide protection against Rocky Mountain spotted fever, we approached the problem of protective immunity to Rickettsia rickettsii with a closely related, live, less pathogenic spotted fever Rickettsia. Guinea pigs vaccinated with R conorii produced antibodies to spotted fever group rickettsiae and did not have fever or other signs of illness after challenge with R rickettsii. A vaccine against Rocky Mountain spotted fever would be useful in some medical practices in the southeastern United States because of the life-threatening nature of the disease, including the possibility of a fulminant course and the frequent difficulty in diagnosis. Further studies should be pursued toward the goal of developing an effective vaccine against Rocky Mountain spotted fever. © 1984 Southern Medical Association. Department of Pathology University of North Carolina School of Medicine, Chapel Hill Department of Pathology Universidade Estadual Paulista, Botucatu, SP Instituto d’lgiene Universita di Palermo Department of Pathology Universidade Estadual Paulista, Botucatu, SP |
| Databáze: | OpenAIRE |
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