Serum cytokines and CXCR2: potential tumour markers in ovarian neoplasms
| Autor: | Rosekeila Simões Nomelini, Beatriz Martins Tavares-Murta, Millena Prata Jammal, Cristiane Naffah de Souza, Agrimaldo Martins-Filho, Eddie Fernando Candido Murta, José Rodolfo Ximenes de Moraes Côrtes, Douglas Côbo Micheli |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Health Toxicology and Mutagenesis Clinical Biochemistry 030204 cardiovascular system & hematology Biochemistry Receptors Interleukin-8B 03 medical and health sciences Chemokine receptor 0302 clinical medicine Neoplasms Biomarkers Tumor Medicine Humans In patient CXC chemokine receptors Ovarian tumours Aged Ovarian Neoplasms business.industry Interleukin-6 Tumor Necrosis Factor-alpha Interleukin-8 Middle Aged Interleukin-10 Gene Expression Regulation Neoplastic Serum cytokine 030220 oncology & carcinogenesis Cancer research Cytokines Interleukin-2 Female Interleukin-5 business |
| Zdroj: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 25(6) |
| ISSN: | 1366-5804 |
| Popis: | The aim was to investigate the systemic levels of cytokines and the expression of the chemokine receptor CXCR2 in circulating neutrophils in patients with non-neoplastic ovarian lesions, benign neoplasia or malignant neoplasia.Controls and patients with ovarian tumours were pre-operatively compared for the production of cytokines (IL-2, IL-5, IL-6, IL-8, IL-10 and TNF-α) by ELISA, and for the expression of the chemokine receptor, CXCR2, in neutrophils, by flow cytometry. Randomly selected patients within the malignant group were re-evaluated for the inflammatory parameters at 30 days after surgery.The serum concentrations of IL-6, IL-8 and IL-10 were significantly higher in the benign and malignant neoplasia than in the control group, and their levels were significantly higher in ovarian cancer patients than in patients with non-neoplastic tumours or benign neoplasia. Treatment reduced IL-8 serum levels but did not affect CXCR2 expression in neutrophils. Cut-off values for IL-6, IL-8, and IL-10 comparing malignant vs. benign neoplasia were 11.3, 71.7, 14.8, and comparing malignant neoplasm vs. non-neoplastic lesions were 7.2, 43.5, 12.3, respectively.Serum IL-6, IL-8, and IL-10 levels, and expression of CXCR2 in circulating neutrophils seem promising for distinguishing ovarian cancer patients from patients with benign tumours. |
| Databáze: | OpenAIRE |
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