Antioxidant and Anti-Inflammatory Activities of the PlantAndrographis PaniculataNees

Autor:	K. Sheeja, P.K. Shihab, G. Kuttan
Rok vydání:	2006
Předmět:	Antioxidant medicine.drug_class medicine.medical_treatment education Immunology Pharmacology Carrageenan Nitric Oxide Toxicology Antioxidants Anti-inflammatory Nitric oxide Lipid peroxidation Mice chemistry.chemical_compound Superoxides In vivo medicine Animals Edema Immunology and Allergy Mice Inbred BALB C Sheep biology Hydroxyl Radical Chemistry Superoxide Anti-Inflammatory Agents Non-Steroidal Free Radical Scavengers General Medicine Oxidants biology.organism_classification Macrophages Peritoneal Tetradecanoylphorbol Acetate Andrographis Lipid Peroxidation Andrographis paniculata
Zdroj:	Immunopharmacology and Immunotoxicology. 28:129-140
ISSN:	1532-2513 0892-3973
DOI:	10.1080/08923970600626007
Popis:	In this study, we explored the antioxidant and anti-inflammatory properties of the medicinal herb Andrographis paniculata using in vitro as well as in vivo systems. Methanolic extract of Andrographis paniculata was found to inhibit formation of oxygen derived free radicals such as superoxide (32%) hydroxyl radicals (80%) lipid peroxidation (80%) and nitric oxide (42.8%) in in vitro system. In vivo studies using BALB/c mice models also showed significant inhibition in PMA induced superoxide (32.4%) and nitric oxide (65.3%) formation. Interestingly we also found that, administration of Andrographis paniculata extract produced complete inhibition of carageenan induced inflammation compared with control models.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512d680cfbeb7bcaf8e1c98691c7a170 https://doi.org/10.1080/08923970600626007 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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