Neurotransmitter Precursor Amino Acid Ratios Show Differential, Inverse Correlations with Depression Severity in the Low and High Depression Score Range
| Autor: | Pia Koudouovoh-Tripp, Dietmar Fuchs, Barbara Sperner-Unterweger, Johanna M. Gostner, Johannes M. Giesinger, Theresa Vill, Katharina Hüfner, Jonas Egeter |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Longitudinal study phenylalanine Physiology QD415-436 Depression score Biochemistry chemistry.chemical_compound Mental stress Internal medicine medicine QP1-981 tryptophan Neurotransmitter Molecular Biology Depression (differential diagnoses) Original Research chemistry.chemical_classification business.industry Depression severity kynurenine Amino acid Endocrinology chemistry quadratic curve fit business tyrosine Kynurenine neurotransmitter Psychoneuroimmunology |
| Zdroj: | International Journal of Tryptophan Research, Vol 14 (2021) International Journal of Tryptophan Research : IJTR |
| ISSN: | 1178-6469 |
| Popis: | The immunomodulatory capacity of mental stress is one of the basic concepts of psychoneuroimmunology. The current prospective longitudinal study was designed to evaluate the effect of acute mental stress on neurotransmitter precursor amino acid levels in individuals with depression at 2 time points. Ten physically healthy patients with a diagnosis of major depressive episode and Montgomery–Åsberg Depression Rating Scale scores (MADRAS) ⩾20 points at inclusion were assessed on 2 study days (once with higher MADRAS scores, once with lower MADRAS scores; median 34.5 days apart) and subjected to a standardized acute mental stress test on each study day. Blood was collected at 4 time points: once prior to and at 3 time points (0, 30 minutes, 60 minutes) following mental stress. Neurotransmitter precursor amino acid levels, that is kynurenine/tryptophan (KYN/TRP) and phenylalanine/tyrosine (PHE/TYR), as well as neopterin and nitrite were analyzed in a total of 80 individual blood samples. Regression and correlation analyses were performed. Regression analyses of PHE/TYR ( R2 = .547) and KYN/TRP ( R2 = .440) in relation to MADRAS depression severity showed a quadratic curve fit. This was reflected by a negative linear correlation between MADRAS scores and PHE/TYR as well as KYN/TRP in the lower score range ( r = −.805, P |
| Databáze: | OpenAIRE |
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