Aortic Stenosis in a Patient With Sjogren's Syndrome
| Autor: | Teiji Okazaki, Shigeaki Aoyagi, Keiichiro Tayama, Michitaka Kono |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Aortic valve
medicine.medical_specialty Exacerbation medicine.medical_treatment 030204 cardiovascular system & hematology Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Valve replacement Internal medicine Severity of illness medicine Humans Aged Autoimmune disease Bioprosthesis Heart Valve Prosthesis Implantation business.industry General Medicine Aortic Valve Stenosis medicine.disease Stenosis medicine.anatomical_structure Sjogren's Syndrome 030228 respiratory system Echocardiography Aortic valve stenosis Cardiology Female Cardiology and Cardiovascular Medicine business Calcification |
| Zdroj: | International heart journal. 57(2) |
| ISSN: | 1349-3299 |
| Popis: | Sjogren's syndrome (SS) is an autoimmune disease characterized by dryness of the mouth and the eyes. Systemic involvement in SS is well known, however, obvious cardiac manifestations, particularly significant valve disorders, are extremely rare and only three cases of significant valve disease associated with SS that required surgical intervention have been previously described. We report a case of aortic stenosis (AS) associated with SS in an elderly patient. The diagnosis of primary SS had been made based on clinical features, positive ocular signs, and positive serologic findings. Echocardiography showed severe calcification, elevated mean pressure gradient (57 mmHg), and a small orifice area (0.45 cm(2)) of the aortic valve. At surgery, severe calcification of the aortic cusps and the annulus was the mechanism of AS, and the aortic valve was replaced with a bioprosthetic valve. Valve pathology showed nodular calcification and hyaline degeneration, but lymphocyte infiltration was not evident. The etiologic relation of SS to the valve lesions is not clear pathologically in this case, however, chronic inflammation related to immunologic reactions in SS could have some effect on exacerbation for degeneration of the valve tissue. |
| Databáze: | OpenAIRE |
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