Serum creatinine and cystatin C provide conflicting evidence of acute kidney injury following acute ingestion of potassium permanganate and oxalic acid
| Autor: | Thilini Wijerathna, Chathura Palanagasinghe, Fahim Mohamed, Zoltan H. Endre, Nicholas A. Buckley, Dhammika Menike Dissanayaka, Fathima Shihana, Gihani Dassanayaka, Indika Gawarammana, Seyed Shahmy |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Time Factors Oxalic acid 030232 urology & nephrology Renal function Suicide Attempted Pharmacology Kidney Toxicology Severity of Illness Index Nephrotoxicity Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Potassium Permanganate Predictive Value of Tests medicine Humans Ingestion Prospective Studies Cystatin C Muscle Skeletal Sri Lanka Creatinine biology urogenital system Oxalic Acid Acute kidney injury Reproducibility of Results General Medicine Acute Kidney Injury medicine.disease Oxidative Stress Potassium permanganate 030104 developmental biology chemistry Biochemistry biology.protein Female Biomarkers Glomerular Filtration Rate |
| Zdroj: | Clinical Toxicology. 55:970-976 |
| ISSN: | 1556-9519 1556-3650 |
| DOI: | 10.1080/15563650.2017.1326607 |
| Popis: | Acute kidney injury (AKI) is common following deliberate self-poisoning with a combination washing powder containing oxalic acid (HMultiple measures of change in kidney function were evaluated in 48 consenting patients who had serial sCr and serum cystatin C (sCysC) data available.Thirty-eight (38/48, 79%) patients developed AKI (AKIN criteria). Twenty-eight (58%) had AKIN stage 2 or 3. Initial increases in urine creatinine (uCr) excretion were followed by a substantial loss of renal function. The AKIN stage 2 and 3 (AKIN2/3) group had very rapid rises in sCr (a median of 118% at 24 h and by 400% at 72 h post ingestion). We excluded the possibility that the rapid rise resulted from the assay used or muscle damage. In contrast, the average sCysC increase was 65% by 72 h.In most AKI, sCysC increases to the same extent but more rapidly than sCr, as sCysC has a shorter half-life. This suggests either a reduction in Cystatin C production or, conversely, that the rapid early rise of sCr results from increased production of creatine and creatinine to meet energy demands following severe oxidative stress mediated by H |
| Databáze: | OpenAIRE |
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