ABL amplification in a patient with lymphoid blast crisis of chronic myelogenous leukaemia
| Autor: | Heinz Sill, Christine Beham-Schmid, Lukas Kenner, Gerald Hoefler, Helmut H. Schmidt, Reinhold Kerbl |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Genes abl Biology Philadelphia chromosome Pathology and Forensic Medicine Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Gene duplication medicine Humans Lymphocytes neoplasms Molecular Biology ABL Gene Amplification breakpoint cluster region Cell Biology General Medicine medicine.disease Reverse transcriptase Blotting Southern Tumor progression Chronic Disease Cancer research Immunohistochemistry Blast Crisis K562 cells |
| Zdroj: | Virchows Archiv. 434:255-257 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s004280050337 |
| Popis: | Although chronic phase myelogenous leukaemia (CML) is characterised by the Philadelphia (Ph) chromosome leading to a fusion of the BCR and ABL genes, additional genetic alterations involved in blast crisis are poorly understood. We report an at least 15-fold amplification of the ABL oncogene in a 29-year-old male patient with a variant Ph-positive t(19;22)(p13;q11.2) CML who presented in lymphoid blast crisis. Our finding suggests that an amplification of the ABL oncogene might play a part in the appearance of an aggressive phenotype in some cases of CML. |
| Databáze: | OpenAIRE |
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