Effect of salmon consumption during pregnancy on maternal and infant faecal microbiota, secretory IgA and calprotectin
| Autor: | Maria Vlachava, Keith M. Godfrey, Norma D. Diaper, Jelena Vulevic, Elizabeth A. Miles, Philip C. Calder, Lefkothea-Stella Kremmyda, Parveen Yaqoob, Paul S. Noakes, Heidi J. Urwin |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Risk Immunoglobulin A medicine.medical_specialty Medicine (miscellaneous) Physiology Gut flora Weight Gain Feces Child Development fluids and secretions Pregnancy Salmon Internal medicine Hypersensitivity medicine Animals Humans Oily fish Single-Blind Method Infant Nutritional Physiological Phenomena Immunity Mucosal Prenatal Nutritional Physiological Phenomena Nutrition and Dietetics biology Infant Newborn biology.organism_classification medicine.disease United Kingdom Intestines Endocrinology Seafood Immunoglobulin A Secretory biology.protein Gestation Female Calprotectin medicine.symptom Leukocyte L1 Antigen Complex Weight gain Biomarkers |
| Zdroj: | British Journal of Nutrition. 111:773-784 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114513003097 |
| Popis: | The gut microbiota plays an important role in the development of the immune and gastrointestinal systems of infants. In the present study, we investigated whether increased salmon consumption during pregnancy, maternal weight gain during pregnancy or mode of infant feeding alter the markers of gut immune defence and inflammation. Women (n123) who rarely ate oily fish were randomly assigned to continue consuming their habitual diet or to consume two 150 g portions of farmed salmon per week from 20 weeks of pregnancy to delivery. Faecal samples were collected from the mothers (n75) at 38 weeks of gestation and from their infants (n38) on days 7, 14, 28 and 84 post-partum. Fluorescencein situhybridisation was used to determine faecal microbiota composition and ELISA to measure faecal secretory IgA (sIgA) and calprotectin concentrations. There was no effect of salmon consumption on maternal faecal microbiota or on maternal or infant faecal sIgA and calprotectin concentrations. The degree of weight gain influenced maternal faecal microbiota, and the mode of infant feeding influenced infant faecal microbiota. Faecal samples collected from infants in the salmon group tended to have lower bacterial counts of theAtopobiumcluster compared with those collected from infants in the control group (P= 0·097). This difference was significant in the formula-fed infants (P |
| Databáze: | OpenAIRE |
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