The potential role of sesquiterpene lactones isolated from medicinal plants in the treatment of the metabolic syndrome – A review

Autor: Anuar Salazar-Gómez, Saudy Saret Pablo-Pérez, M. Elena Vargas-Dı́az, Julio C. Ontiveros-Rodríguez, Leticia Garduño-Siciliano
Rok vydání: 2020
Předmět:
IL-1β
interleukin 1 beta
0106 biological sciences
GSH
reduced glutathione
Structural diversity
Review
Plant Science
01 natural sciences
G6Pase
glucose-6-phosphatase
Hypolipidemic
chemistry.chemical_compound
Broad spectrum
IR
insulin resistance
TBARS
thiobarbituric acid reactive substances
FFA
free fatty acids
TNF-α
tumor necrosis factor alpha
AMPK
activated protein kinase
Medicinal plants
STAT1
signal transducer and activator of transcription 1
NF-κB
nuclear factor kappa B
GPx
glutathione peroxidase
SLns
sesquiterpene lactones
JNK
c-Jun N-terminal kinases
Biological activity
TG
triglycerides
Metabolic syndrome
IL-6
interleukin 6
iNOS
inducible nitric oxide synthase
LPS
lipopolysaccharide
MetS
metabolic syndrome
Sesquiterpene lactones
COX-2
cyclooxygenase 2
GK
glucokinase
MCP-1
monocyte chemoattractant protein 1
Computational biology
CVD
cardiovascular disease
Biology
Sesquiterpene
STZ
streptozotocin
Tc total cholesterol
ROS
reactive oxygen species
SOD
superoxide dismutase
AT
adipose tissue
medicine
LDL-C
low-density lipoprotein-cholesterol
Beneficial effects
FN
fibronectin
TLRs
Toll-like receptor
NO
nitric oxide
IFN-γ
interferon gamma
HDL-C
high-density lipoproteins-cholesterol
VLDL
very-low-density lipoprotein
T2DM
type 2 diabetes mellitus
Hypoglycemic
medicine.disease
ACE
angiotensin I-converting enzyme
0104 chemical sciences
APOC3
apolipoprotein C3
TC
total cholesterol
TGF-β1
transforming growth factor beta
010404 medicinal & biomolecular chemistry
Antidiabetic
chemistry
MAPK
mitogen-activated protein kinases
CAT
catalase
010606 plant biology & botany
Zdroj: South African Journal of Botany
ISSN: 0254-6299
DOI: 10.1016/j.sajb.2020.08.020
Popis: Highlights • Definition and pathogenesis of metabolic syndrome is briefly described. • Sesquiterpene lactones isolated from medicinal plants used in traditional medicine. • In vivo and in vitro biological activities of sesquiterpene lactones are considered. • Chemical and biological properties of natural sesquiterpene lactones are documented.
Metabolic syndrome comprises a cluster of metabolic disorders related to the development of cardiovascular disease and type 2 diabetes mellitus. In latter years, plant secondary metabolites have become of special interest because of their potential role in preventing and managing metabolic syndrome. Sesquiterpene lactones constitute a large and diverse group of biologically active compounds widely distributed in several medicinal plants used for the treatment of metabolic disorders. The structural diversity and the broad spectrum of biological activities of these compounds drew significant interests in the pharmacological applications. This review describes selected sesquiterpene lactones that have been experimentally validated for their biological activities related to risk factors of metabolic syndrome, together with their mechanisms of action. The potential beneficial effects of sesquiterpene lactones discussed in this review demonstrate that these substances represent remarkable compounds with a diversity of molecular structure and high biological activity, providing new insights into the possible role in metabolic syndrome management.
Databáze: OpenAIRE
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