High resolution 7T MR imaging in characterizing culprit intracranial atherosclerotic plaques
| Autor: | Rami Fakih, Alberto Varon Miller, Ashrita Raghuram, Sebastian Sanchez, Jacob M Miller, Sedat Kandemirli, Chengcheng Zhu, Amir Shaban, Enrique C Leira, Edgar A Samaniego |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Interventional Neuroradiology. :159101992211457 |
| ISSN: | 2385-2011 1591-0199 |
| DOI: | 10.1177/15910199221145760 |
| Popis: | Background Current imaging modalities underestimate the severity of intracranial atherosclerotic disease (ICAD). High resolution vessel wall imaging (HR-VWI) MRI is a powerful tool in characterizing plaques. We aim to show that HR-VWI MRI is more accurate at detecting and characterizing intracranial plaques compared to digital subtraction angiography (DSA), time-of-flight (TOF) MRA, and computed tomography angiogram (CTA). Methods Patients with symptomatic ICAD prospectively underwent 7T HR-VWI. We calculated: degree of stenosis, plaque burden (PB), and remodeling index (RI). The sensitivity of detecting a culprit plaque for each modality as well as the correlations between different variables were analyzed. Interobserver agreement on the determination of a culprit plaque on every imaging modality was evaluated. Results A total of 44 patients underwent HR-VWI. Thirty-four patients had CTA, 18 TOF-MRA, and 18 DSA. The sensitivity of plaque detection was 88% for DSA, 78% for TOF-MRA, and 76% for CTA. There's significant positive correlation between PB and degree of stenosis on HR-VWI MRI (p Conclusions The degree of stenosis measured by intra-luminal techniques does not fully reflect the true extent of ICAD. HR-VWI is a more accurate tool in characterizing atherosclerotic plaques and may be the default imaging modality in clinical practice. |
| Databáze: | OpenAIRE |
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