Unexpected substitution of dominant rotavirus G genotypes in French hospitalized children over five consecutive seasons

Autor: Laurent Fourcade, Jérôme Kaplon, D. Gendrel, Frédéric Huet, François Denis, M.-J. El-Hajje, Pierre Lebon, Sophie Alain, Jérôme Grosjean, A. de Rougemont, Pierre Pothier
Přispěvatelé: Laboratoire Interactions Muqueuses Agents Transmissibles ( LIMA ), Université de Bourgogne ( UB ), Laboratoire de Virologie, Hôpital Cochin-St. Vincent-de-Paul (AP-HP), Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier ( LIRMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Teaching hospital, Apoptose, cancer et immunité ( U848 ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut Gustave Roussy ( IGR ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Génomes et cancer ( GC (FRE2939) ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut Gustave Roussy ( IGR ) -Centre National de la Recherche Scientifique ( CNRS ), Département de Pédiatrie, Hôpital Saint Vincent de Paul, Laboratoire de sérologie-virologie (CHU de Dijon), Laboratoire Interactions Muqueuses Agents Transmissibles (LIMA), Université de Bourgogne (UB), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Apoptose, cancer et immunité (U848), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génomes et cancer (GC (FRE2939)), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Humbert, Murielle, Biologie moléculaire et cellulaire des microorganismes (EA3175), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Limoges (UNILIM), Biomolécules Thérapies anti-tumorales (EA4021), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Service de chirurgie pédiatrique viscérale, orthopédique et plastique [CHU Limoges], CHU Limoges
Rok vydání: 2008
Předmět:
Rotavirus
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
viruses
medicine.disease_cause
Feces
fluids and secretions
Medical microbiology
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Genotype
Prospective Studies
Prospective cohort study
Child
Antigens
Viral
ComputingMilieux_MISCELLANEOUS
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
0303 health sciences
biology
Reverse Transcriptase Polymerase Chain Reaction
virus diseases
General Medicine
Hospitals
3. Good health
Infectious Diseases
Child
Preschool
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Acute Disease
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
France
Microbiology (medical)
Diarrhea
medicine.medical_specialty
Adolescent
Reoviridae
[ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Rotavirus Infections
03 medical and health sciences
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Genomics [q-bio.GN]
medicine
Humans
Typing
Serotyping
030304 developmental biology
Molecular epidemiology
030306 microbiology
business.industry
Infant
Newborn
Infant
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
biology.organism_classification
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Virology
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
El Niño
Capsid Proteins
business
Zdroj: European Journal of Clinical Microbiology and Infectious Diseases
European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2009, pp.403-7
European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2009, 28 (4), pp.403-407. ⟨10.1007/s10096-008-0640-1⟩
ISSN: 1435-4373
0934-9723
DOI: 10.1007/s10096-008-0640-1⟩
Popis: International audience; The study was designed to evaluate the circulation of group A rotaviruses in French hospitalized children, and to detect unusual strains. This prospective study was conducted from 2001 to 2006 in children consulting for acute diarrhea at the pediatric emergency department in three French University Hospitals. The rotaviruses were detected by rapid test and genotyped by RT-PCR on the basis of their outer capsid proteins VP4 (P-type) and VP7 (G-type). The stools from 757 children were analyzed. G1P[8] strains were predominant (44.0%), followed by G9P[8] (17.7%), G3P[8] 13.1%, G4P[8] (9.5%), and G2P[4] (1.8%); mixed rotavirus infections occurred in 2.3%. G9 rotaviruses emerged during the 2004-2005 season (73.4%) and remained the second most prevalent strains. Few unusual strains, G6, G8, G12 and P[6]-types, were detected. The monitoring of rotavirus infections should be maintained to document strain distribution and to assess the emergence of new reassortants that may not respond to current rotavirus vaccines.
Databáze: OpenAIRE
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