A structurally abnormal insulin causing human diabetes
| Autor: | Arthur H. Rubenstein, James J Markese, Mary E. Mako, B D Given, Howard S. Tager, Russel Poucher, Masashi Kobayashi, O. Kolterman, Jerrold M. Olefsky, D. Baldwin |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Heterozygote
medicine.medical_specialty medicine.medical_treatment Islets of Langerhans Structure-Activity Relationship Downregulation and upregulation Diabetes mellitus Insulin receptor substrate Internal medicine Diabetes Mellitus medicine Humans Insulin Amino Acid Sequence Multidisciplinary biology Chemistry medicine.disease Receptor Insulin Insulin oscillation Insulin receptor Endocrinology medicine.anatomical_structure Mutation biology.protein Insulin Resistance Pancreas Hormone |
| Zdroj: | Nature. 281:122-125 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/281122a0 |
| Popis: | Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studies suggest that the isolated hormone is a mixture of normal insulin and an abnormal variant which contains a leucine for phenylalanine substitution at position 24 or 25 of the insulin B-chain. |
| Databáze: | OpenAIRE |
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