HLA polymorphism in Moroccan Jewry
| Autor: | Lior Shapira, Chaim Brautbar, Adam Friedmann, Cilly Safirman, I. Cohen, Michael Sela, Anat Roitberg-Tambur, Leontina Sherman, W. Aubrey Soskolne, Shoshana Battat, Campbell S. Witt, Shlomit Eisenberg |
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| Rok vydání: | 1994 |
| Předmět: |
Judaism
Immunology Population Human leukocyte antigen Biology Polymerase Chain Reaction Gene Frequency HLA Antigens Community living Humans Immunology and Allergy Israel Allele education Alleles Genetics education.field_of_study Polymorphism Genetic Haplotype Class I Antigens General Medicine Morocco Phenotype Haplotypes Genetic distance Jews |
| Zdroj: | Human Immunology. 40:61-67 |
| ISSN: | 0198-8859 |
| Popis: | The Moroccan Jewish community living in Israel shows a relatively large genetic distance from other North African Jewish communities. In this work the polymorphism of HLA class I and class II determinants, as defined by serology and oligotyping, is analyzed in 113 healthy unrelated Jews of Moroccan stock. The class I antigens HLA-A1, -B44, and -Cw7 showed the highest frequency, while the most prevalent class II variants were DRB1 ∗ 0701 and ∗ 1104, DQA1 ∗ 0501, and DQB1 ∗ 0201 and ∗ 0301. HLA A1-B13-DR7, A2-B51-DR10, and A1-B44-DR13 were the most typical three-locus haplotypes. Although the antigen frequency distribution of the Moroccan Jews falls within the Caucasian diversity range, this community has a unique pattern in terms of antigen, gene, and haplotype frequencies. Thus, in the Moroccan Jews DRB1 ∗ 1305, an allele believed to be the result of a recombination event between DRB1 ∗ 1301–1302 and DRB1 ∗ 1101, is represented to a much larger extent than in all the other population groups studied at the 11th IHWS. This allele may therefore be a typical Jewish variant. A particular finding was the high frequencies of HLA-B13, B52, and DR10, alleles common among some Oriental populations. The answer to this enigmatic phenomenon probably must be sought in the tortuous history of this community. |
| Databáze: | OpenAIRE |
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