Geographic variation of genotype 6 hepatitis C virus infection in an endemic area of southern Taiwan
| Autor: | Chun-Ta Cheng, Hsu-Ju Kao, Jyh-Jou Chen, Hung-Da Tung, Tang-Wei Chuang, Hsin-Hua Tsai, Li-Ching Wu, Pei-Lun Lee, Chuan Lee, Ming-Jen Sheu, Hsing-Tao Kuo, Chia-Yi Hou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Veterinary medicine
Genotype Hepatitis C virus Southern taiwan Prevalence Taiwan Geographic variation Viremia Hepacivirus Geographic varisation medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Medicine Humans lcsh:R5-920 business.industry Endemic area General Medicine medicine.disease Hepatitis C Subtyping Genotype 6 hepatitis C virus 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology HCV subtype 6g business lcsh:Medicine (General) |
| Zdroj: | Journal of the Formosan Medical Association, Vol 119, Iss 12, Pp 1876-1880 (2020) |
| ISSN: | 0929-6646 |
| Popis: | Taiwan is a hepatitis C virus (HCV) endemic country with geographic variation of prevalence and main genotypes(GTs) are 1 b and 2a. We recently reported high GT6 prevalence in Tainan of southern Taiwan. To clarify this special genotype as a local endemic disease and its geographic variation, the prevalence rates of HCV GTs of 37 districts of Tainan were analyzed. A total of 3040 patients with HCV viremia were enrolled. The prevalence rates of HCV GT 1a, 1 b, 2, 3, 4, 6 and mixed types were 3.9%, 31.6%, 45.9%, 0.6%, 0.2%, 17.1% and 0.5% respectively. GT6 prevalence showed marked variation from 0 to 39.2%. Four districts with GT6 prevalence >30% are located between Jishui and Zengwen rivers. Preliminary subtyping data were 6 g/a/w. This geographic variation with spatial restriction by two rivers with 6 g/w is suggestive of local endemic infection of preexisting GT 6 HCV for centuries. |
| Databáze: | OpenAIRE |
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