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Victor Aleksandrovich Stupin N.I. Pirogov Russian National Research Medical University (RNRMU), 117997, Russia, Moscow, Ostrovityanova St., 1 Ekaterina Vladimirovna Silina I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991, Russia, Moscow, Trubetskaya St., 8 Sergey Yurievich Zhidkih N.I. Pirogov Russian National Research Medical University (RNRMU), 117997, Russia, Moscow, Ostrovityanova St., 1 Ruslan Borisovich Gabitov I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991, Russia, Moscow, Trubetskaya St., 8 Evgeny Anatolyevich Bogdanov Immanuel Kant Baltic Federal University (IKBFU), 236041, Russia, Kaliningrad, Nevskiy St., 14 Abstract Object:To improve the results of treatment of patients with diabetic foot syndrome, including the use of collagen biomaterial. Materials and methods. We have made a multicentre study with the participation of 71 patients with diabetic foot syndrome of different severity levels. The patients were randomized into two homogeneous groups: 1) group of standard therapy (n=35); and 2) group with additional administration of collagen biomaterial (Collost/Salvecoll) (n=36). The dynamic assessment of patients was performed when including into the study and on the 7th, 14th and 28th day of treatment. Results. The use of collagen biomaterial was attended by the faster and more effective healing of the ulcerative defect. The wound area decreased mainly due to reduction in its width, while the success of the treatment increased 1.7 times. The additional use of collagen biomaterial led to a significant increase in the incidence rate of complete epithelialization of the defect against the background of a reduction in the incidence rate of ineffective treatment. The correlation analysis performed has shown that a favorable result expressed in a good or complete wound/ulcer healing is associated with small defect size, Wagner II without signs of pronounced infection and ischemization and with the use of collagen biomaterial. Keywords:diabetic foot syndrome, trophic ulcer size, epithelialization, collagen, Collost, Salvecoll. https://www.sechenov.ru/science_and_innovation/repo/?PAGEN_1=15#134873 |
