Risk factors for early-onset colorectal cancer: a population-based case–control study in Ontario, Canada
| Autor: | Vicky C. Chang, Prithwish De, Jill Tinmouth, Michelle Cotterchio |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Sugary drinks Population Early-onset colorectal cancer Young Adult 03 medical and health sciences 0302 clinical medicine Epidemiology Humans Medicine Family history education Ontario Original Paper education.field_of_study business.industry Incidence (epidemiology) Case-control study Odds ratio Random digit dialing Diet Cancer registry Sedentary behavior Risk factors Oncology Case-Control Studies 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology Colorectal Neoplasms business Demography |
| Zdroj: | Cancer Causes & Control |
| ISSN: | 1573-7225 0957-5243 |
| DOI: | 10.1007/s10552-021-01456-8 |
| Popis: | Purpose There has been an alarming increase in colorectal cancer (CRC) incidence among young adults aged Methods A population-based case–control study was conducted in Ontario, Canada during 2018–2019. EO-CRC cases aged 20–49 years (n = 175) were identified from the Ontario Cancer Registry; sex- and age group-matched controls (n = 253) were recruited through random digit dialing. Data on potential a priori risk factors were collected using a web-based self-reported questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression. Results Family history of CRC in a first- or second-degree relative (OR 2.37; 95% CI 1.47–3.84), longer sedentary time (≥ 10 vs. Conclusion Modifiable factors, particularly sedentary behavior and unhealthy diet including sugary drink consumption, may be associated with EO-CRC risk. Our findings, if replicated, may help inform prevention strategies targeted at younger persons. |
| Databáze: | OpenAIRE |
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