Transcranial direct current stimulation induces hippocampal metaplasticity mediated by brain-derived neurotrophic factor

Autor: Kuei Sen Hsu, Yi Jen Wu, Miao Er Chien, Ting Hsuan Yu
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
medicine.medical_treatment
Adrenergic beta-Antagonists
Long-Term Potentiation
Stimulation
Tropomyosin receptor kinase B
Hippocampal formation
Transcranial Direct Current Stimulation
Rats
Sprague-Dawley
Tissue Culture Techniques
03 medical and health sciences
Cellular and Molecular Neuroscience
Random Allocation
0302 clinical medicine
Memory
Metaplasticity
medicine
Avoidance Learning
Animals
Receptor
trkB
CA1 Region
Hippocampal
Pharmacology
Brain-derived neurotrophic factor
Transcranial direct-current stimulation
Chemistry
musculoskeletal
neural
and ocular physiology
Brain-Derived Neurotrophic Factor
Receptors
Dopamine D1
Long-term potentiation
Azepines
Propranolol
030104 developmental biology
nervous system
Brain stimulation
Benzamides
Synapses
2
3
4
5-Tetrahydro-7
8-dihydroxy-1-phenyl-1H-3-benzazepine
Neuroscience
030217 neurology & neurosurgery
Zdroj: Neuropharmacology. 144
ISSN: 1873-7064
Popis: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique used to modulate neuronal excitability via externally applied electric fields. Despite the positive effects of tDCS in a wide range of neurological disorders in humans, its mechanism of action remains poorly understood. Here we investigated cellular and molecular mechanisms underlying the aftereffects of anodal tDCS on the induction of long-term potentiation (LTP), a cellular correlate of learning and memory, at Schaffer collateral-CA1 synapses. We found that hippocampal CA1 LTP was enhanced in slices from rats subjected to anodal tDCS with no significant changes in basal synaptic function. The enhancing effect of tDCS on LTP was still maintained 12 h after stimulation. Treatment of ex vivo hippocampal slices from tDCS-treated rats with tropomyosin receptor kinase B (TrkB) inhibitor ANA-12, but not D1 receptor antagonist SKF-83566 or β2-adrenergic receptor antagonist propranolol, efficiently prevented tDCS-induced enhancement of LTP. The tDCS-treated rats exhibited higher levels of brain derived neurotrophic factor (BDNF) in the hippocampal CA1 region compared to sham-treated rats. Anodal tDCS also enhances memory performance in hippocampal-dependent passive avoidance learning task, and this enhancement can be blocked by ANA-12 pretreatment. Altogether, our results underscore the importance of BDNF/TrkB-mediated metaplastic effect of anodal tDCS on the induction of hippocampal CA1 LTP.
Databáze: OpenAIRE
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