Solvent directed chemically divergent synthesis of β-lactams and α-amino acid derivatives with chiral isothiourea
| Autor: | Dong-Sheng Ji, Hui Liang, Kai-Xuan Yang, Zhi-Tao Feng, Yong-Chun Luo, Guo-Qiang Xu, Yucheng Gu, Peng-Fei Xu |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Chemical Science. 13:1801-1807 |
| ISSN: | 2041-6539 2041-6520 |
| Popis: | A protocol for the chemically divergent synthesis of β-lactams and α-amino acid derivatives with isothiourea (ITU) catalysis by switching solvents was developed. The stereospecific Mannich reaction occurring between imine and C(1)-ammonium enolate generated zwitterionic intermediates, which underwent intramolecular lactamization and afforded β-lactam derivatives when DCM and CH |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|