Acute hypobaric-hypoxia challenge and salivary cortisol and DHEA-S in healthy male subjects
Autor: | Roberto Biselli, Pontremolesi S, Ciniglio Appiani G, Patacchioli Fr, Simona S, Raffaele D'Amelio |
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Rok vydání: | 2012 |
Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone military aviators Altitude Sickness cortisol/dhea-s ratio Reference Values Stress Physiological Internal medicine Medicine Humans Stress resilience Hypoxia Saliva Salivary cortisol Analysis of Variance business.industry Dehydroepiandrosterone Sulfate Matched control Public Health Environmental and Occupational Health Hypoxia (medical) Endocrinology Military Personnel Hypobaric chamber Area Under Curve salivary stress hormones Hypobaric hypoxia medicine.symptom business hormones hormone substitutes and hormone antagonists Hormone |
Zdroj: | Aviation, space, and environmental medicine. 83(7) |
ISSN: | 0095-6562 |
Popis: | BACKGROUND Hypobaric hypoxia is a stressful emergency situation that can cause a degradation of the sensory, motor, and higher cognitive functions necessary for safe flight. METHODS We studied the salivary cortisol and dehydroepiandrosterone-sulfate (DHEA-S) concentrations of 12 healthy male military aviators (AV) exposed to an altitude-induced hypoxia challenge in a hypobaric chamber. A matched control group (C) of eight flight physiology instructors wearing oxygen masks during the challenge was studied. Salivary samples were collected every 2 h on 3 experimental days (the day before, the day of, and the day after the hypobaric chamber challenge). RESULTS In the AV group, salivary cortisol concentrations showed a statistically significant increase from 5.42 +/- 0.15 measured at 08:30 to 11.37 +/- 1.86 ng ml(-1) during the hypobaric chamber challenge and a statistically significant increase in DHEA-S was also measured (from 3.15 +/- 0.42 ng x ml(-1) at 08:30 to 5.99 +/- 0.15 ng x ml(-1)). The day after the challenge, the concentrations of both hormones were comparable to those measured the day before; neither C nor AV showed any disturbances of the physiological diurnal fluctuations of cortisol and DHEA-S. No differences were found among the cortisol/DHEA-S ratios measured during the 3 experimental days in the AV group. DISCUSSION In spite of having experienced a psycho-physical stress, the AVs did not show any dysregulation of the diurnal fluctuations of cortisol and DHEA-S, thus presenting a good level of stress resilience. Data presented in this paper are consistent with recent literature suggesting a stress-buffering role of DHEA-S. |
Databáze: | OpenAIRE |
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