Formulation and optimization of pH sensitive drug releasing O/W emulsions using Albizia lebbeck L. seed polysaccharide
| Autor: | K. Jayaram Kumar, Chekuri Ashok Kumar Varma |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Polymers
Chemistry Pharmaceutical Dispersity Albizzia 02 engineering and technology 01 natural sciences Biochemistry Smart polymer Excipients Drug Delivery Systems Drug Stability Structural Biology Polysaccharides 0103 physical sciences Zeta potential Particle Size Molecular Biology chemistry.chemical_classification 010304 chemical physics Viscosity General Medicine Polymer Factorial experiment 021001 nanoscience & nanotechnology Drug Liberation chemistry Targeted drug delivery Emulsifying Agents Drug delivery Emulsion Seeds Emulsions 0210 nano-technology Rheology Nuclear chemistry |
| Zdroj: | International journal of biological macromolecules. 116 |
| ISSN: | 1879-0003 |
| Popis: | Smart polymers, one of the class of polymers with extensive growth in the last few decades due to their wide applications in drug targeting and controlled delivery systems. With this in mind, the aim of the present study is to design and formulate smart releasing o/w emulsion by using Albizia lebbeck L. seed polysaccharide (ALPS). For this purpose, the physicochemical and drug release characteristics like emulsion capacity (EC), emulsion stability (ES), viscosity, microscopy, zeta potential, polydispersity index (PDI) and in-vitro drug release were performed. The EC and ES values were found to increase with an increased concentration of ALPS. The emulsion formulations were statistically designed by using 32 full factorial design. All the emulsions showed a shear-thinning behavior. The zeta potential and polydispersity index were found to be in the range of -35.83 mV to -19.00 mV and 0.232-1.000 respectively. Further, the percent cumulative drug release of the emulsions at 8 h was found to be in the range of 30.19-82.65%. The drug release profile exhibited zero order release kinetics. In conclusion, the ALPS can be used as a natural emulsifier and smart polymer for the preparation of pH sensitive emulsions in drug delivery systems. |
| Databáze: | OpenAIRE |
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