Overexpression of genes involved in lymphocyte activation and regulation are associated with reduced CRM-derived cardiac remodelling after STEMI

Autor: E De Dios, M F Forteza, José M. Vila, Cesar Rios-Navarro, Jose Gavara, Vicent Bodí, Nerea Perez-Sole, Ricardo Oltra, Víctor Marcos-Garcés, Francisco J. Chorro
Rok vydání: 2021
Předmět:
Antigens
Differentiation
T-Lymphocyte
Male
0301 basic medicine
medicine.medical_specialty
Lymphocyte
medicine.medical_treatment
Programmed Cell Death 1 Receptor
Immunology
Gene Expression
chemical and pharmacologic phenomena
Lymphocyte proliferation
Lymphocyte Activation
03 medical and health sciences
0302 clinical medicine
Antigens
CD
Internal medicine
Humans
Immunology and Allergy
Medicine
Cytotoxic T cell
CTLA-4 Antigen
Lectins
C-Type
IL-2 receptor
Myocardial infarction
Gene
Aged
Pharmacology
Ventricular Remodeling
business.industry
Interleukin-2 Receptor alpha Subunit
Percutaneous coronary intervention
Heart
hemic and immune systems
Odds ratio
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Pathophysiology
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cancer research
Lymphocyte activation
Leukocytes
Mononuclear
Cardiology
ST Elevation Myocardial Infarction
Female
Cardiology and Cardiovascular Medicine
business
Zdroj: International Immunopharmacology. 95:107490
ISSN: 1567-5769
Popis: Aims Lymphopenia after ST-segment elevation myocardial infarction (STEMI) correlates with deleterious cardiac consequences and worse prognosis. An in-depth examination of genes implicated in lymphocyte proliferation, activation and regulation and their association with short- and long-term cardiac structure and function is therefore of great interest. Methods Peripheral blood mononuclear cells were isolated from 10 control subjects and 64 patients with a first STEMI treated with primary percutaneous coronary intervention and submitted to cardiac magnetic resonance after 1 week and 6 months. mRNA expression of genes implicated in lymphocyte activation (CD25 and CD69) and regulation [programmed death (PD)-1 and cytotoxic T-lymphocyte antigen (CTLA)-4] were determined by qRT-PCR. Results In comparison to controls, STEMI patients showed heightened mRNA expression of CD25 and lower PD-1 and CTLA-4 96h after coronary reperfusion. Patients with extensive infarctions (>30% of left ventricular mass) at 1 week displayed a notable reduction in CD25, CD69, PD-1, and CTLA-4 expression (p Conclusions Following STEMI, heightened expression of genes expressed in regulatory T cells (CD25 and CD69) and immune checkpoints (PD-1 and CTLA-4) correlates with a better short- and long-term cardiac structure and function. Advancing understanding of the pathophysiology of lymphopenia and evaluating novel immunomodulatory therapies will help translate these results into future clinical trials. Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): “Instituto de Salud Carlos III” and “Fondos Europeos de Desarrollo Regional FEDER”
Databáze: OpenAIRE
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