Overexpression of genes involved in lymphocyte activation and regulation are associated with reduced CRM-derived cardiac remodelling after STEMI
Autor: | E De Dios, M F Forteza, José M. Vila, Cesar Rios-Navarro, Jose Gavara, Vicent Bodí, Nerea Perez-Sole, Ricardo Oltra, Víctor Marcos-Garcés, Francisco J. Chorro |
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Rok vydání: | 2021 |
Předmět: |
Antigens
Differentiation T-Lymphocyte Male 0301 basic medicine medicine.medical_specialty Lymphocyte medicine.medical_treatment Programmed Cell Death 1 Receptor Immunology Gene Expression chemical and pharmacologic phenomena Lymphocyte proliferation Lymphocyte Activation 03 medical and health sciences 0302 clinical medicine Antigens CD Internal medicine Humans Immunology and Allergy Medicine Cytotoxic T cell CTLA-4 Antigen Lectins C-Type IL-2 receptor Myocardial infarction Gene Aged Pharmacology Ventricular Remodeling business.industry Interleukin-2 Receptor alpha Subunit Percutaneous coronary intervention Heart hemic and immune systems Odds ratio Middle Aged medicine.disease Magnetic Resonance Imaging Pathophysiology 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research Lymphocyte activation Leukocytes Mononuclear Cardiology ST Elevation Myocardial Infarction Female Cardiology and Cardiovascular Medicine business |
Zdroj: | International Immunopharmacology. 95:107490 |
ISSN: | 1567-5769 |
Popis: | Aims Lymphopenia after ST-segment elevation myocardial infarction (STEMI) correlates with deleterious cardiac consequences and worse prognosis. An in-depth examination of genes implicated in lymphocyte proliferation, activation and regulation and their association with short- and long-term cardiac structure and function is therefore of great interest. Methods Peripheral blood mononuclear cells were isolated from 10 control subjects and 64 patients with a first STEMI treated with primary percutaneous coronary intervention and submitted to cardiac magnetic resonance after 1 week and 6 months. mRNA expression of genes implicated in lymphocyte activation (CD25 and CD69) and regulation [programmed death (PD)-1 and cytotoxic T-lymphocyte antigen (CTLA)-4] were determined by qRT-PCR. Results In comparison to controls, STEMI patients showed heightened mRNA expression of CD25 and lower PD-1 and CTLA-4 96h after coronary reperfusion. Patients with extensive infarctions (>30% of left ventricular mass) at 1 week displayed a notable reduction in CD25, CD69, PD-1, and CTLA-4 expression (p Conclusions Following STEMI, heightened expression of genes expressed in regulatory T cells (CD25 and CD69) and immune checkpoints (PD-1 and CTLA-4) correlates with a better short- and long-term cardiac structure and function. Advancing understanding of the pathophysiology of lymphopenia and evaluating novel immunomodulatory therapies will help translate these results into future clinical trials. Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): “Instituto de Salud Carlos III” and “Fondos Europeos de Desarrollo Regional FEDER” |
Databáze: | OpenAIRE |
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