Acromegaly and Hyperthyroidism Associated with McCune-Albright Syndrome
| Autor: | Moriharu Misaki, Kazutaka Morioka, Teruo Shima, Jiro Ikoma, Shiro Suzuki |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male musculoskeletal diseases endocrine system medicine.medical_specialty Somatotroph hyperplasia endocrine system diseases Endocrinology Diabetes and Metabolism Fibrous Dysplasia Polyostotic Hyperthyroidism McCune–Albright syndrome Endocrinology Internal medicine Acromegaly Humans Medicine Cold nodule Goiter business.industry Thyroid Fibrous Dysplasia of Bone medicine.disease medicine.anatomical_structure Adenomatous goiter business Sexual precocity hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Hormone Research. 30:26-27 |
| ISSN: | 1423-0046 0301-0163 |
| DOI: | 10.1159/000181021 |
| Popis: | A 36-year-old man is described having McCune-Albright syndrome, acromegaly likely due to somatotroph hyperplasia and hyperthyroidism due to adenomatous goiter. Sexual precocity was not noted. The sella was narrow in size and no mass was seen. The decline of elevated GH by hyperglycemia and increase by GHRH-44(NH2) may support somatotroph hyperplasia, but plasma GHRH-44(NH2) levels were not elevated. A mass in the right lobe and enlargement of the left lobe of the thyroid were noted. Thyroid hormone levels in serum and thyroidal radioiodine uptake values were elevated, while TSH measurements in serum were low. The radioiodine scan showed a cold nodule in the right lobe and a hot area in the left of the thyroid. Thyroidal radioiodine was not suppressed following T3 given orally. These findings are compatible with functioning glands autonomously as the mechanism for the endocrinopathies associated with the McCune-Albright syndrome. |
| Databáze: | OpenAIRE |
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