Prognostic factors in stage AO B-cell chronic lymphocytic leukaemia
| Autor: | M. Fitchett, R. M. Pickering, Terry J. Hamblin, David Oscier, J. Stevens |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Surface Immunoglobulin Lymphocyte Chronic lymphocytic leukemia Immunoglobulins Gastroenterology Hemoglobins Leukocyte Count Sex Factors Internal medicine Complex Karyotype medicine Humans Lymphocytes Stage (cooking) Aged Neoplasm Staging Aged 80 and over business.industry Age Factors Karyotype Hematology Middle Aged Prognosis medicine.disease Leukemia Lymphocytic Chronic B-Cell Phenotype Lymphocyte Subsets medicine.anatomical_structure Karyotyping Female business Progressive disease |
| Zdroj: | British Journal of Haematology. 76:348-351 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1990.tb06366.x |
| Popis: | Summary 85 patients presenting to a single centre with stage AO B-cell chronic lymphocytic leukaemia (B-CLL) have been studied. The duration of follow-up has ranged from a minimum of 1 year to a maximum of 18 years with a mean of 6 years. 14 patients have had progressive disease and 23 patients have died, of whom nine had CLL-related deaths. We assessed the prognostic significance of the following parameters: age at presentation, sex, haemoglobin concentration, initial lymphocyte count, surface membrane phenotype. serum immunoglobulin levels at presentation and karyotype. None of these factors were predictive of survival, but there was a correlation between initial lymphocyte count, surface immunoglobulin MDλ phenotype, and complex karyotypic abnormalities and disease progression. Two patients with a complex karyotype have been followed for more than 5 years without evidence of progression. |
| Databáze: | OpenAIRE |
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