A novel haemocytometric COVID-19 prognostic score developed and validated in an observational multicentre European hospital-based study
| Autor: | Marion Münster, Jurgen A Riedl, Anthonius Dofferhof, Joachim Linssen, Jarob Saker, Mathie P. G. Leers, Annelies Verbon, Henk Russcher, Yvette Kluiters-de Hingh, Volkher Scharnhorst, Lucas Joost Van Pelt, André J. A. M. van der Ven, Marvin A.H. Berrevoets, Judith M.E.P. Gillis, Giulia Previtali, Simone van der Sar-van der Brugge, Imke C. A. Munnix, Michela Seghezzi, Stephan J. L. Bakker, Anthony Ermens, Heidi S. M. Ammerlaan, Eva de Jongh, Kathleen Deiteren |
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| Přispěvatelé: | Clinical Chemistry, Internal Medicine, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male complete blood count Prognostic score Cohort Studies 0302 clinical medicine Symptom duration Medicine Clinical severity Biology (General) intensive care Aged 80 and over medicine.diagnostic_test General Neuroscience Complete blood count General Medicine Middle Aged Prognosis Hospitals prognostic score Europe Hospitalization 030220 oncology & carcinogenesis Female Cell activation Research Article Human Adult medicine.medical_specialty Adolescent Coronavirus disease 2019 (COVID-19) QH301-705.5 Science CORONAVIRUS DISEASE 2019 PERIPHERAL-BLOOD DIAGNOSIS General Biochemistry Genetics and Molecular Biology ROUTINE Hospital based study 03 medical and health sciences Young Adult All institutes and research themes of the Radboud University Medical Center Intensive care Internal medicine Humans haemocytometry Pandemics Biology Aged Retrospective Studies General Immunology and Microbiology SARS-CoV-2 business.industry COVID-19 Blood Cell Count 030104 developmental biology lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] CELLS Observational study Human medicine business |
| Zdroj: | eLife Elife, 9 eLife, 9:e63195, 1-37. eLife Sciences Publications eLife, 9. ELIFE SCIENCES PUBLICATIONS LTD eLife, 9:63195. ELIFE SCIENCES PUBLICATIONS LTD eLife, Vol 9 (2020) |
| ISSN: | 2050-084X |
| DOI: | 10.7554/elife.63195 |
| Popis: | COVID-19 induces haemocytometric changes. Complete blood count changes, including new cell activation parameters, from 982 confirmed COVID-19 adult patients from 11 European hospitals were retrospectively analysed for distinctive patterns based on age, gender, clinical severity, symptom duration and hospital days. The observed haemocytometric patterns formed the basis to develop a multi-haemocytometric-parameter prognostic score to predict, during the first three days after presentation, which patients will recover without ventilation or deteriorate within a two-week timeframe, needing intensive care or with fatal outcome. The prognostic score, with ROC curve AUC at baseline of 0.753 (95% CI 0.723-0.781) increasing to 0.875 (95% CI 0.806-0.926) on day 3, was superior to any individual parameter at distinguishing between clinical severity. Findings were confirmed in a validation cohort. Aim is that the score and haemocytometry results are simultaneously provided by analyser software, enabling wide applicability of the score as haemocytometry is commonly requested in COVID-19 patients. |
| Databáze: | OpenAIRE |
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