Autor: |
Ross C. Hardison, Saurabh K. Bhardwaj, Carolyne J. Face, Stella T. Chou, Christopher R. Edwards, Stephen A. Liebhaber, Gerd A. Blobel, Xianjiang Lan, Ben A. Garcia, Junwei Shi, Laavanya Sankaranarayanan, David Posocco, Simone Sidoli, Belinda Giardine, Nicole Hamagami, Osheiza Abdulmalik, Jeremy D. Grevet, Cheryl A. Keller, Xinjun Ji |
Rok vydání: |
2018 |
Předmět: |
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Zdroj: |
Science. 361:285-290 |
ISSN: |
1095-9203 0036-8075 |
Popis: |
A CRISPR screen for RBC regulators Hemoglobin in red blood cells (RBCs) carries oxygen to the tissues. Sickle cell disease is an inherited condition that involves abnormal hemoglobin. Current treatments entail modulating the level of fetal hemoglobin expression. Grevet et al. performed a CRISPR-Cas9 screen for regulators of fetal hemoglobin in RBCs and identified heme-regulated eIF2α kinase (HRI). Depleting the kinase in RBCs led to an increase in fetal hemoglobin levels and reduced sickling of cultured human RBCs. Thus, HRI may be a therapeutic target for sickle cell disease and other hemoglobin disorders. Science , this issue p. 285 |
Databáze: |
OpenAIRE |
Externí odkaz: |
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