Au nanorings for enhancing absorption and backscattering monitored with optical coherence tomography
| Autor: | Hung-Yu Tseng, Kai-Min Yang, Cheng-Kuang Lee, Yang Che Wu, Han Yi E. Chou, Yean-Woei Kiang, Chih-Chung Yang, Jyh Yang Wang, Shou Yen Wu, Meng-Tsan Tsai, Chun-Pin Chiang, Ting Ta Chi |
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| Rok vydání: | 2010 |
| Předmět: |
Materials science
Opacity Surface Properties Swine Bioengineering Optics Optical coherence tomography parasitic diseases medicine Animals General Materials Science Electrical and Electronic Engineering medicine.diagnostic_test Scattering business.industry Mechanical Engineering Photothermal effect General Chemistry Surface Plasmon Resonance Photothermal therapy Nanostructures Wavelength Adipose Tissue Mechanics of Materials Microscopy Electron Scanning Gold business Tomography Optical Coherence Nanoring Localized surface plasmon |
| Zdroj: | Nanotechnology. 21:295102 |
| ISSN: | 1361-6528 0957-4484 |
| DOI: | 10.1088/0957-4484/21/29/295102 |
| Popis: | Preparation of a high-concentration Au nanoring (NR) water solution and its applications to the enhancement of image contrast in optical coherence tomography (OCT) and the generation of the photothermal effect in a bio-sample through localized surface plasmon (LSP) resonance are demonstrated. Au NRs are first fabricated on a sapphire substrate with colloidal lithography and secondary sputtering of Au, and then transferred into a water solution through a liftoff process. By controlling the NR geometry, the LSP dipole resonance wavelength in tissue can cover a spectral range of 1300 nm for OCT scanning of deep tissue penetration. The extinction cross sections of the fabricated Au NRs in water are estimated to give levels of 10(-10)-10(-9) cm(2) near their LSP resonance wavelengths. The fabricated Au NRs are then delivered into pig adipose samples for OCT scanning. It is observed that, when resonant Au NRs are delivered into such a sample, LSP resonance-induced Au NR absorption results in a photothermal effect, making the opaque pig adipose cells transparent. Also, the delivered Au NRs in the intercellular substance enhance the image contrast of OCT scanning through LSP resonance-enhanced scattering. By continuously OCT scanning a sample, both photothermal and image contrast enhancement effects are observed. However, by continually scanning a sample with a low scan frequency, only the image contrast enhancement effect is observed. |
| Databáze: | OpenAIRE |
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