Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors
| Autor: | Jean-Michel Dogné, Charlotte Bouckaert, Raphaël Frédérick, Johan Wouters, Eduard Dolusic, Silvia Serra, Grégoire Rondelet, Lionel Pochet |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.drug_class Factor XIIa medicine.medical_treatment Carboxamide 030204 cardiovascular system & hematology Coumarins Factor XII FXII antithrombotic agents benzopyrans 03 medical and health sciences Structure-Activity Relationship 0302 clinical medicine Fibrinolytic Agents Zymogen Drug Discovery medicine Structure–activity relationship Humans Homology modeling Pharmacology Protease Chemistry Organic Chemistry General Medicine Combinatorial chemistry Amides Molecular Docking Simulation 030104 developmental biology Docking (molecular) |
| Zdroj: | European journal of medicinal chemistry / Chimica therapeutica. :181-194 |
| ISSN: | 1768-3254 0223-5234 |
| Popis: | Inhibitors of the coagulation factor XIIa (FXIIa) are attractive to detail the roles of this protease in hemostasis and thrombosis, to suppress artifact due to contact pathway activation in blood coagulation assays, and they are promising as antithrombotic therapy. The 3-carboxamide coumarins have been previously described as small-molecular-weight FXIIa inhibitors. In this study, we report a structure-activity relationship (SAR) study around this scaffold with the aim to discover new selective FXIIa inhibitors with an improved physico-chemical profile. To better understand these SAR, docking experiments were undertaken. For this purpose, we built an original hybrid model of FXIIa. This model has the advantage to gather the best features from the recently published crystal structure of FXIIa in its zymogen form and a more classical homology model. Results with the hybrid model are encouraging as they help understanding the activity and selectivity of our best compounds. |
| Databáze: | OpenAIRE |
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