Resistance of Neisseria gonorrhoeae to ingestion and digestion by phagocytes of human buffy coat

Autor:	K. Witt, D. R. Veale, H. Smith
Rok vydání:	1976
Předmět:	Microbiology (medical) Virulence Strain (chemistry) Neutrophils Phagocytosis Cell Count General Medicine Buffy coat Biology medicine.disease_cause Microbiology Virology Monocytes Neisseria gonorrhoeae In vitro Species Specificity medicine Humans Ingestion Digestion
Zdroj:	Journal of Medical Microbiology. 9:1-12
ISSN:	1473-5644 0022-2615
Popis:	In tests in vitro with the phagocytes of human buffy coat, a recent isolate of Neisseria gonorrhoeae, which was pilated, formed small colonies and resembled the virulent Kellogg type 2 (strain BS), resisted ingestion more than did another isolate (strain AL), which was non-pilated, formed large colonies and resembled the avirulent Kellogg type 4. Some members of both strains survived for significant periods within the phagocytes in test conditions that tended to minimise rather than maximise such survival; and strain BS had a greater capacity for intracellular survival than strain AL, with some of its members surviving for at least 8 h. Resistance to phagocytic ingestion is one important invasive mechanism of gonococci, and resistance to phagocytic digestion may also play a role in pathogenicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5107e4e6a989da839223093c04e11451 https://doi.org/10.1099/00222615-9-1-1 Zobrazit plný text záznamu