Characterization of the PEG layer of sterically stabilized liposomes: a SAXS study
| Autor: | U. Vainio, András Wacha, J. Gummel, Zoltán Varga, Attila Bóta |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Electron density
Lipid Bilayers Electrons chemistry [Lipid Bilayers] macromolecular substances 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Polyethylene Glycols chemistry.chemical_compound X-Ray Diffraction Scattering Small Angle PEG ratio Molecule Molecular Biology Liposome Molar mass Small-angle X-ray scattering chemistry [Liposomes] Bilayer Organic Chemistry technology industry and agriculture Cell Biology 021001 nanoscience & nanotechnology 0104 chemical sciences Crystallography chemistry [Polyethylene Glycols] chemistry ddc:540 Liposomes Quantum Theory 0210 nano-technology Ethylene glycol |
| Zdroj: | Chemistry and physics of lipids 165, 387-392 (2012). doi:10.1016/j.chemphyslip.2011.12.011 |
| ISSN: | 0009-3084 |
| DOI: | 10.1016/j.chemphyslip.2011.12.011 |
| Popis: | Synchrotron small-angle X-ray scattering analysis of the bilayer structure of a pharmacologically relevant sterically stabilized liposome system is presented. Describing the electron density profile of the bilayer with the superposition of Gaussian functions, the contribution of the poly(ethylene glycol) (PEG) layers to the total electron density was identified. The changes in the thickness of the PEG layer as well as the distribution of the PEG chains among the outer and inner leaflets of the bilayers were followed by changing the molar ratio of the PEG-lipid and the molar weight of the PEG molecule. |
| Databáze: | OpenAIRE |
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