Metabolic factors involved in the interaction between pyrazole and butane-1, 4-diol and 4-hydroxybutyric acid
| Autor: | P.V. Taberner, J.T. Rick, G.A. Kerkut |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Stereochemistry medicine.drug_class Diol Hydroxybutyrates Alcohol oxidoreductase Motor Activity Pyrazole General Biochemistry Genetics and Molecular Biology Glycols Mice chemistry.chemical_compound medicine Animals Drug Interactions General Pharmacology Toxicology and Pharmaceutics Alcohol dehydrogenase Behavior Animal biology Brain Butane General Medicine NAD Mice Inbred C57BL Alcohol Oxidoreductases Liver chemistry Sedative biology.protein Pyrazoles NAD+ kinase Sleep Oxidation-Reduction |
| Zdroj: | Life Sciences. 11:335-341 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(72)90059-8 |
| Popis: | It is confirmed that pyrazole prevents the sleep-inducing effect of butane-1, 4-diol in mice. In addition, it is shown that pyrazole potentiates 4-hydroxybutyrate-induced sleep but has no effect on succinic semialdehyde-induced sleep. Pyrazole itself has a slight sedative action at doses above 450 mg/Kg. Mouse liver extract and liver alcohol dehydrogenase readily oxidise butane-1, 4-diol (K M 1.6 × 10 −3 M). This oxidation is competitively inhibited by pyrazole (K I 5.4 × 10 −7 M). It is proposed that this inhibition provides the basis for the interaction between pyrazole and butane-1, 4-diol. |
| Databáze: | OpenAIRE |
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