Cytological Anal Squamous Intraepithelial Lesions Associated with Anal High-Risk Human Papillomavirus Infections among Men Who Have Sex with Men in Northern Thailand
| Autor: | Taweewat Supindham, Radchanok Songsupa, Quanhathai Kaewpoowat, Utaiwan Utaipat, Toshiyuki Miura, Kornkanok Sukpan, Suwat Chariyalertsak, Jongkolnee Settakorn, Natthapol Kosashunhanan, Darin Ruanpeng, Antika Wongthanee, Pongpun Saokhieo |
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| Rok vydání: | 2016 |
| Předmět: |
Male
RNA viruses Viral Diseases Human immunodeficiency virus (HIV) lcsh:Medicine Pathology and Laboratory Medicine medicine.disease_cause Men who have sex with men Geographical Locations 0302 clinical medicine Immunodeficiency Viruses Risk Factors Prevalence Medicine and Health Sciences 030212 general & internal medicine Young adult lcsh:Science Papillomaviridae Multidisciplinary Obstetrics virus diseases Middle Aged Thailand Infectious Diseases Oncology Sexual behavior Medical Microbiology Viral Pathogens 030220 oncology & carcinogenesis Viruses Female Squamous Intraepithelial Lesions of the Cervix Pathogens Papanicolaou Test Research Article Adult Human Papillomavirus Infection medicine.medical_specialty Asia Adolescent Genotype Sexual Behavior Urology Sexually Transmitted Diseases Men WHO Have Sex with Men Gastroenterology and Hepatology Anal and Rectal Disorders Microbiology Young Adult 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Retroviruses medicine Humans Anal cancer Homosexuality Male Human papillomavirus Condyloma Acuminata Microbial Pathogens Gynecology Anus Diseases Condyloma acuminata Gender identity Genitourinary Infections business.industry Papillomavirus Infections Lentivirus lcsh:R Sexual Preferences Organisms Biology and Life Sciences HIV Cancers and Neoplasms Cell Biology medicine.disease People and Places Anal Cancer Lesions Population Groupings lcsh:Q Cytology business |
| Zdroj: | PLoS ONE, Vol 11, Iss 5, p e0156280 (2016) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Anal cancer, one of human papillomavirus (HPV) related malignancies, has increased in recent decades, particularly among men who have sex with men (MSM) and HIV-infected (HIV+) persons. We aimed to explore the prevalence of anal squamous intraepithelial lesions (ASIL) using Papanicolau (Pap) screening among MSM in northern Thailand and its associated factors. Methods Two hundreds MSM aged ≥18 years reporting receptive anal intercourse in the prior 6 months were recruited from July 2012 through January 2013. Medical history and behavioral data were collected by staff interview and computer-assisted self interview. Anal Pap smear, HPV genotyping, and HIV testing were performed. Two pathologists blinded to HPV and HIV status reported cytologic results by Bethesda classification. Results Mean age was 27.2 years (range 18–54). Overall, 86 (43.0%) had ASIL: 28 (14.2%) with atypical cells of undetermined significance (ASCUS), 1 (0.5%) with atypical squamous cells—cannot exclude high-grade squamous intraepithelial lesion (ASC-H), 56 (28.4%) with low-grade squamous intraepithelial lesion (LSIL), and 1 (0.5%) with high-grade squamous intraepithelial lesion (HSIL). ASIL was associated by univariate analysis (p ≤0.05) with older age, gender identity other than bisexual (i.e., gay men and transgender women), rectal douching, anal symptoms, genital warts, HIV positivity, and high-risk-HPV infection. However, on multiple logistic regression ASIL was associated only with high-risk HPV type (p = 0.002) and HIV infection (p = 0.01). Conclusions ASIL is quite common in high-risk MSM in northern Thailand and is associated with high-risk HPV types and HIV infection. Routine anal Pap screening should be considered, given the high frequency of ASIL, particularly in the HIV+. High resolution anoscopy (HRA), not done here, should be to confirm PAP smears whose sensitivity and specificity are quite variable. Timely HPV vaccination should be considered for this population. |
| Databáze: | OpenAIRE |
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