TRC150094, a novel functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high‐fat diet

Autor:	Ramesh Chandra Gupta, Rosa Anna Busiello, Shitalkumar Zambad, Chaitanya Dutt, Pieter de Lange, Davinder Tuli, Rosalba Senese, Vijay Chauthaiwale, Fernando Goglia, Maria Moreno, Laxmikant Chhipa, Federica Cioffi, Elena Silvestri, Assunta Lombardi, Siralee Munshi, Antonia Lanni
Přispěvatelé:	Cioffi, F, Zambad, Sp, Chhipa, L, Senese, R, Busiello, Ra, Tuli, D, Munshi, S, Moreno, M, Lombardi, Assunta, Gupta, Rc, Chauthaiwale, V, Dutt, C, de Lange, P, Silvestri, E, Lanni, A, Goglia, F., Senese, Rosalba, Lombardi, A, DE LANGE, Pieter, Lanni, Antonia
Rok vydání:	2010
Předmět:	Male medicine.medical_specialty Blotting Western Thyrotropin Blood lipids Adipose tissue Hepatic steatosi Biology Biochemistry Eating chemistry.chemical_compound Overnutrition Sirtuin 1 Internal medicine Thyronines Genetics medicine Animals Obesity Rats Wistar Molecular Biology Beta oxidation Triglycerides Adiposity Carnitine O-Palmitoyltransferase Cholesterol Body Weight Fatty Acids digestive oral and skin physiology nutritional and metabolic diseases food and beverages Lipid metabolism medicine.disease Dietary Fats Rats Mitochondria Thyroid hormone Thyroxine Endocrinology chemistry Triiodothyronine lipids (amino acids peptides and proteins) medicine.symptom Energy Metabolism Oxidation-Reduction Weight gain hormones hormone substitutes and hormone antagonists Biotechnology
Zdroj:	The FASEB Journal. 24:3451-3461
ISSN:	1530-6860 0892-6638
Popis:	Chronic overnutrition and modern life-styles are causing a worldwide epidemic of obesity and associated comorbidities, which is creating a demand to identify underlying biological mechanisms and to devise effective treatments. In rats receiving a high-fat diet (HFD), we analyzed the effects of a 4-wk administration of a novel functional analog of iodothyronines, TRC150094 (TRC). HFD-TRC rats exhibited increased energy expenditure (+24% vs. HFD rats; P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51004b25469455f1e071b7d7541af1c3 https://doi.org/10.1096/fj.10-157115 Zobrazit plný text záznamu Plný text