Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile
| Autor: | Denis Richard, Isabelle Lemieux, Pascale Mauriège, Sylvie Caspar-Bauguil, Amélie Cartier, Simon Biron, Jean Bergeron, Picard Marceau, Denis R. Joanisse |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Hydrocortisone Physiology Adipose Tissue White Adipose tissue Adipokine Inflammation Biology Biochemistry chemistry.chemical_compound Insulin resistance Adipokines Metabolic Diseases Internal medicine medicine Humans RNA Messenger Fatty acid metabolism Adiponectin General Medicine Middle Aged medicine.disease Obesity Morbid Endocrinology chemistry Organ Specificity Female medicine.symptom Insulin Resistance Transcriptome Homeostasis Biomarkers Metabolic Networks and Pathways medicine.drug |
| Zdroj: | Journal of physiology and biochemistry. 71(4) |
| ISSN: | 1877-8755 |
| Popis: | Despite well-established variations in the health risks posed by visceral vs. subcutaneous abdominal (SCABD) fat depots, surprisingly little is known on the differences within a given adipose tissue (AT) among severely obese patients displaying varying metabolic dysfunction. We thus compared, by quantitative PCR, the expression profile of a number of genes in the SCABD, omental (OME), and mesenteric (MES) depots of severely obese women with (DYS; n = 25) or without (NDYS; n = 23) a dysmetabolic profile. Fasting insulinemia and HOmeostasis Model Assessment-insulin resistance (HOMA-IR) were higher and plasma adiponectin level lower in DYS women (p |
| Databáze: | OpenAIRE |
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