Involvement of CD4+Cells in Lymphocytic Choriomeningitis Virus-Induced Autoimmune Anaemia and Hypergammaglobulinaemia
| Autor: | S J Johnston, Jean-Paul Coutelier, C J Pfau, M el-A El Idrissi |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
CD4-Positive T-Lymphocytes
Erythrocytes medicine.drug_class Lymphocyte Lymphocyte Cooperation Immunology Monoclonal antibody Lymphocytic choriomeningitis Virus Autoimmune Diseases Mice Immune system Hypergammaglobulinemia medicine Animals Lymphocytic choriomeningitis virus Immunology and Allergy B cell Autoimmune disease Mice Inbred C3H Arenavirus biology medicine.disease biology.organism_classification Virology medicine.anatomical_structure Female Anemia Hemolytic Autoimmune |
| Zdroj: | Journal of Autoimmunity. 7:589-599 |
| ISSN: | 0896-8411 |
| Popis: | Development of pathology varies widely between different strains of mice after intracerebral inoculation with the so-called 'docile' isolate of Lymphocytic Choriomeningitis (LCM) virus. The C3HeB/FeJ and B10. Br/SgSnJ mouse strains have been of special interest because they display autoimmune haemolytic anaemia with varying degrees of apparent immunological involvement. In this report, we examined the role of CD4+ T helper cells in this autoimmune response by treating mice with the CD4-specific GK1.5 monoclonal antibody. We also determined if polyclonal activation of B lymphocytes, induced either by LCM virus or by lactate dehydrogenase-elevating virus, another well known B cell activator, correlated with the development of anaemia in these mice. Our results strengthened the central role of the immune system in the anaemia in C3H mice by showing that depletion of CD4+ cells largely, if not completely, abrogated this anti-erythrocyte autoimmune reaction. As reported by others, we found that the anaemia was more mild in B10.BR mice than in C3H mice. However, we could not confirm the difference in the degree of B lymphocyte polyclonal activation between these mice. Furthermore, lactate dehydrogenase-elevating virus had no apparent effect on erythrocytes, even though this virus also induced a sharp increase in plasma IgG levels. |
| Databáze: | OpenAIRE |
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