Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome

Autor:	Ferdinand Althammer, Moritz Claudius Wimmer, Quirin Krabichler, Stephanie Küppers, Jonas Schimmer, Henning Fröhlich, Laura Dötsch, Tim Gruber, Selina Wunsch, Tim Schubert, Matthew K. Kirchner, Javier E. Stern, Alexandre Charlet, Valery Grinevich, Christian P. Schaaf
Rok vydání:	2022
Předmět:	Male Endocrine and Autonomic Systems Endocrinology Diabetes and Metabolism Neuropeptides Hypothalamus Proteins Oxytocin Cellular and Molecular Neuroscience Mice Disease Models Animal Endocrinology Receptors Oxytocin Antigens Neoplasm Astrocytes Humans Animals Female Prader-Willi Syndrome
Zdroj:	Journal of neuroendocrinologyREFERENCES. 34(12)
ISSN:	1365-2826
Popis:	Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by hyperphagia, obesity, developmental delay and intellectual disability. Studies suggest dysfunctional signaling of the neuropeptide oxytocin as one of the key mechanisms in PWS, and administration of oxytocin via intranasal or systemic routes yielded promising results in both humans and mouse models. However, a detailed assessment of the oxytocin system in mouse models of PWS such as the Magel2-deficient Magel2
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fe29fafd6811e1010cfb69af7d62b5 https://pubmed.ncbi.nlm.nih.gov/36458331 Zobrazit plný text záznamu Plný text