Therapeutic drug monitoring and methods of quantitation for carbamazepine
| Autor: | Denisa Oana Balalau, Cristina Dinu Pirvu, Ana Maria Vlasceanu, Cristian Tuchila, Daniela Luiza Baconi, Miriana Stan, Cristian Balalau |
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| Rok vydání: | 2017 |
| Předmět: |
validation
lcsh:R5-920 medicine.diagnostic_test business.industry therapeutic drug monitoring 010401 analytical chemistry bioanalytical method Carbamazepine Pharmacology medicine.disease 01 natural sciences humanities 0104 chemical sciences 03 medical and health sciences Epilepsy 0302 clinical medicine Therapeutic drug monitoring carbamazepine medicine epilepsy natural sciences lcsh:Medicine (General) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Mind and Medical Sciences, Vol 4, Iss 2, Pp 100-114 (2017) |
| ISSN: | 2392-7674 |
| DOI: | 10.22543/7674.42.p100114 |
| Popis: | Carbamazepine is an early anticonvulsant still used today in the treatment of several forms of epilepsy. An active metabolite in the human body contributes to its pharmacological effect. Carbamazepine metabolism has high inter-individual variability, such that it is relatively difficult to establish a direct link between dose and concentration, or between concentration and pharmacological effect. Carbamazepine is thus a good candidate for therapeutic drug monitoring (TDM). Good UV specific absorbance and high plasmatic concentrations allow for the use of UV detection, which is often more accessible than other methods of detection. This paper presents several methods used for the detection of carbamazepine in plasma, methods that are capable of detecting drug and metabolites at adequate levels/ acceptance criteria. These methods have possible application not only in pharmacokinetic, bioequivalence, and permeability studies, but also in the therapeutic drug monitoring of carbamazepine. |
| Databáze: | OpenAIRE |
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