Anogenital squamous cell carcinoma in neglected patient
| Autor: | Pavel Babal, M Havrankova, E Weismanova, D Svecova |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Bubo
Economics and Econometrics Pathology medicine.medical_specialty Skin Neoplasms Lesion Materials Chemistry Media Technology Carcinoma Medicine Humans Neoplasm Invasiveness Lymph node Skin Neoplasm Vulvar Neoplasms business.industry Forestry Middle Aged medicine.disease Anus Neoplasms medicine.anatomical_structure Carcinoma Squamous Cell Buttocks Histopathology Female Lymph medicine.symptom Skin cancer business |
| Zdroj: | Bratislavske lekarske listy. 113(4) |
| ISSN: | 0006-9248 |
| Popis: | Skin squamous cell carcinomas (SCCs) are arguably the second most common carcinoma of the skin and are responsible for the majority of non-melanoma skin cancer deaths. Gynecologist treated a Caucasian 56-years old female patient for genital wart with podophyllotoxin cream. She did not achieve complete response and therefore she has interrupted the therapy and the collaboration with the gynecologist. At the time of evaluation the lesion had a size of man's palm in anogenital region and showed characteristic features of neoplasm. The regional lymph nodes have produced infiltrated painful bubo. PCR analysis for HPV proved negative. Histopathology revealed well-differentiated squamous cell keratinizing carcinoma from the tumor as well as from the regional lymph node packet. Staging computed tomography scans proved negative and pelvis scans disclosed regional lymphadenopathy underlying the tumor. Palliative radiation therapy (by linear accelerator) was administered for the oversized tumor to the total TD 50.0Gy. The patient died 6 months after diagnostic assessment from cardio-respiratory failure. Staging computed tomography before her death did not disclose distinct metastases in her inner organs. Well-differentiated squamous cell keratinizing carcinoma could be growing endophytically affecting the underlying adipose tissue and musculature, with spreading into the regional lymph nodes. The rate of metastases into inner organs seems to vary according to the aggressiveness and metastatic behavior of each SCC. The case report calls for attention to the importance of collaboration among various specialists assisting in the diagnosis and management of skin neoplasm (Fig. 5, Ref. 12). Full Text in PDF www.elis.sk. |
| Databáze: | OpenAIRE |
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