Could pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?
Autor: | Elda Gonçalves dos Santos, Eliziária C. Santos, Reggiani Vilela Gonçalves, Izabel Regina dos Santos Costa Maldonado, Antônio José Natali, André Talvani, Thaiany G. Souza-Silva, Rômulo Dias Novaes |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Chagas disease Male Myocarditis Cardiotonic Agents medicine.medical_treatment Trypanosoma cruzi 030106 microbiology Parasitemia 030204 cardiovascular system & hematology Pharmacology medicine.disease_cause Drug Administration Schedule Running 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physical Conditioning Animal medicine Animals Chagas Disease Rats Wistar Chemotherapy biology Antiparasitic Agents Heart Glutathione medicine.disease biology.organism_classification Rats Disease Models Animal Infectious Diseases chemistry Benznidazole Nitroimidazoles Cytokines Animal Science and Zoology Parasitology Oxidative stress medicine.drug |
Zdroj: | Parasitology. 146(13) |
ISSN: | 1469-8161 |
Popis: | Considering a potential exercise-drug interaction, we investigated whether exercise training could improve the efficacy of specific antiparasitic chemotherapy in a rodent model of Chagas disease. Wistar rats were randomized into five groups: sedentary and uninfected (CT); sedentary and infected (SI); sedentary, infected and treated (SIT); trained and infected (TI); trained, infected and treated (TIT). After 9-weeks running training, the animals were infected with T. cruzi and followed up for 4 weeks, receiving 100 mg kg−1 day−1 benznidazole. No evidence of myocarditis was observed in CT animals. TI animals exhibited reduced parasitemia, myocarditis, and reactive tissue damage compared to SI animals, in addition to increased IFN-γ, IL-4, IL-10, heart non-protein antioxidant (NPA) levels and glutathione-s transferase activity (P < 0.05). The CT, SIT and TIT groups presented similar reductions in parasitemia, cytokines (IFN-γ, TNF-α, IL-4, IL-10, IL-17 and MCP-1), inflammatory infiltrate, oxidative heart damage and antioxidant enzymes activity compared to SI and TI animals, as well as reduced heart microstructural remodeling (P < 0.05). By modulating heart inflammation and redox metabolism, exercise training exerts a protective effect against T. cruzi infection in rats. However, the antiparasitic and cardioprotective effects of benznidazole chemotherapy are more pronounced, determining similar endpoints in sedentary and trained T. cruzi-infected rats. |
Databáze: | OpenAIRE |
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