Salicylate acutely stimulates 5′-AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscles

Autor:	Yasuhiro Serizawa, Kazuto Kitani, Ayumi Goto, Rieko Oshima, Mitsuki Yoshida, Satoshi Tsuda, Tatsuya Hayashi, Ichika Sakon
Rok vydání:	2014
Předmět:	Male Threonine medicine.medical_specialty Glucose transport Biophysics Skeletal muscle Biological Transport Active P70-S6 Kinase 1 AMP-Activated Protein Kinases Biochemistry Rats Sprague-Dawley Diabetes mellitus Internal medicine parasitic diseases medicine Animals Hypoglycemic Agents Insulin Glucose homeostasis Phosphorylation Muscle Skeletal Molecular Biology Protein kinase B Salicylate biology Chemistry AMPK Cell Biology Rats IRS1 5′-AMP-activated protein kinase Insulin signaling Insulin receptor Glucose Muscle Fibers Slow-Twitch Endocrinology medicine.anatomical_structure Muscle Fibers Fast-Twitch biology.protein Energy Metabolism Salicylic Acid GLUT4 Signal Transduction
Zdroj:	Biochemical and Biophysical Research Communications. 453:81-85
ISSN:	0006-291X
DOI:	10.1016/j.bbrc.2014.09.066
Popis:	Salicylate (SAL) has been recently implicated in the antidiabetic effect in humans. We assessed whether 5'-AMP-activated protein kinase (AMPK) in skeletal muscle is involved in the effect of SAL on glucose homeostasis. Rat fast-twitch epitrochlearis and slow-twitch soleus muscles were incubated in buffer containing SAL. Intracellular concentrations of SAL increased rapidly (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f546b339e5a7c416027e0aac6b2e76 https://doi.org/10.1016/j.bbrc.2014.09.066 Zobrazit plný text záznamu Full Text from ScienceDirect