Toward the total synthesis of the brasilinolides: stereocontrolled assembly of a C1-C19 polyol segment

Autor:	Christopher J. Cordier, Michael P. Housden, Olivier Loiseleur, Paul M. Burton, Friedrich A. Mühlthau, Ian Paterson
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Aldehydes Stereochemistry Chemistry Polymers Protein subunit Organic Chemistry Total synthesis Stereoisomerism Biochemistry Carbon Polyol Aldol reaction Organic chemistry Macrolides Physical and Theoretical Chemistry
Zdroj:	Organic letters. 11(2)
ISSN:	1523-7052
Popis:	Two highly convergent syntheses of a fully protected C1−C19 polyol subunit of the brasilinolide family of immunosuppressive macrolides are described, exploiting boron-mediated 1,5-anti aldol couplings to form the C8−C9 and C13−C14 bonds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f5056667d20cbbea921d0142336dfd https://pubmed.ncbi.nlm.nih.gov/19072327 Zobrazit plný text záznamu