Potential Immune Mechanisms Associated with Anemia in Plasmodium vivax Malaria: a Puzzling Question
| Autor: | Érika Martins Braga, Gisely Cardoso de Melo, Marcus V. G. Lacerda, Thiago Castro-Gomes, Luiza Carvalho Mourão, Wuelton Marcelo Monteiro |
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| Rok vydání: | 2014 |
| Předmět: |
biology
Anemia Immunology Plasmodium vivax medicine.disease biology.organism_classification Microbiology Pathogenesis Infectious Diseases Immune system parasitic diseases Malaria Vivax medicine biology.protein Humans Parasitology Minireview Plasmodium vivax Malaria Antibody Malaria Immune mechanisms |
| Zdroj: | Infection and Immunity. 82:3990-4000 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.01972-14 |
| Popis: | The pathogenesis of malaria is complex, generating a broad spectrum of clinical manifestations. One of the major complications and concerns in malaria is anemia, which is responsible for considerable morbidity in the developing world, especially in children and pregnant women. Despite its enormous health importance, the immunological mechanisms involved in malaria-induced anemia remain incompletely understood. Plasmodium vivax , one of the causative agents of human malaria, is known to induce a strong inflammatory response with a robust production of immune effectors, including cytokines and antibodies. Therefore, it is possible that the extent of the immune response not only may facilitate the parasite killing but also may provoke severe illness, including anemia. In this review, we consider potential immune effectors and their possible involvement in generating this clinical outcome during P. vivax infections. |
| Databáze: | OpenAIRE |
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