Is Allopurinol Beneficial in the Prevention of Renal Ischaemia—Reperfusion Injury in the Rat?: Evaluation by Near-Infrared Spectroscopy
| Autor: | G. I. Russell, Peter Rolfe, Maureen S. Thorniley, EP Ruban, R. Houston, DL Vaughan, Y. A. B. D. Wickramasinghe |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Pathology Ischaemia-reperfusion injury Allopurinol Ischemia Urology Rat kidney Renal function Kidney Rats Sprague-Dawley Hemoglobins Random Allocation In vivo medicine Animals business.industry General Medicine medicine.disease Rats medicine.anatomical_structure Oxyhemoglobins Reperfusion Injury business Reperfusion injury medicine.drug |
| Zdroj: | Clinical Science. 88:359-364 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs0880359 |
| Popis: | 1. The role of allopurinol in the protection of kidney function following ischaemia—reperfusion injury has been investigated using the novel technique of near-infrared spectroscopy. 2. An in vivo model of rat kidney ischaemia was used, with the expected falls in blood and tissue oxygenation seen and confirmed by near-infrared spectroscopy. 3. Allopurinol infusion increased the rate of reperfusion of oxygenated blood seen in control rats (P < 0.05). 4. Allopurinol enhanced the rate of tissue oxygenation during early reperfusion (P < 0.01). 5. This study provides further evidence for the proposed benefits of allopurinol in ischaemia—reperfusion injury. Furthermore, the potential of near-infrared spectroscopy as a technique of value in interventional studies of this nature is confirmed. |
| Databáze: | OpenAIRE |
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