Effect of patient thickness on acute gastrointestinal toxicities following radiotherapy for prostate cancer
| Autor: | Jose Couto, Paul Bezzina, Robert Pisani |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
separation medicine.medical_treatment EPIC Gastroenterology Prostate cancer Patient age Internal medicine medicine Radiology Nuclear Medicine and imaging gastrointestinal toxicity Lymph node business.industry Incidence (epidemiology) Confounding medicine.disease prostate cancer thickness Radiation therapy medicine.anatomical_structure Oncology Gastrointestinal system -- Cancer Toxicity Prostate -- Cancer business Patients -- Care Research Paper patient size |
| Zdroj: | Reports of Practical Oncology and Radiotherapy |
| ISSN: | 1507-1367 |
| Popis: | Background: There is conflicting literature regarding the effect of patient size on radiotherapy toxicities. This study aimed to determine whether there is any association between patient thickness and severity and incidence of acute GI toxicities of prostate cancer patients receiving VMAT radiotherapy. The impact of confounding factors was also examined: rectal dose, age and lymph node irradiation. Materials and methods: This study used a non-experimental, retrospective, descriptive and crosssectional design. All patients who complied with the inclusion criteria (n = 96) were included. GI toxicity scores (baseline and last week of radiotherapy), rectal dose, lymph nodes irradiation and patient age at diagnosis were collected from the treatment file. Patient separations were measured from the CT-Simulator images. Statistical tests were performed to analyse the influence of these factors on acute GI toxicities. Results: Patient thickness was shown to have no statistically significant effect on the incidence (p = 0.947 for antero-posterior and p = 0.839 for lateral thicknesses), and severity (p = 0.986 and 0.905, respectively) of acute GI toxicities. Severity of GI toxicities increased following radiotherapy: the Expanded Prostate Cancer Index Composite (EPIC) score increased by 2.64 from baseline (p < 0.001). The confounding factors had no statistically significant effect on toxicities (p > 0.05). Conclusion: As expected, most patients experienced an increase in GI toxicity following radiotherapy. No relationship was established between patient thickness and the severity or incidence of acute GI toxicities, adding to the existing body of knowledge. Therefore, all patients should receive adequate follow up, irrespective of size. Side-effect recording tools should be implemented systematically for continuous assessment of this relationship. peer-reviewed |
| Databáze: | OpenAIRE |
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