Progression of mild cognitive impairment to Alzheimer's disease: improved diagnostic value of the combined use of N200 latency and beta-amyloid(1-42) levels
| Autor: | George Koliakos, George Anogianakis, V K Kimiskidis, Magdalini Tsolaki, Vasileios Papaliagkas |
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| Rok vydání: | 2009 |
| Předmět: |
Oncology
Male medicine.medical_specialty Cognitive Neuroscience Disease Electroencephalography Neuropsychological Tests Central nervous system disease Cerebrospinal fluid Degenerative disease Discrimination Psychological Alzheimer Disease Internal medicine medicine Humans Latency (engineering) Aged Amyloid beta-Peptides medicine.diagnostic_test Cognitive disorder medicine.disease Peptide Fragments Psychiatry and Mental health Disease Progression Evoked Potentials Auditory Female Geriatrics and Gerontology Alzheimer's disease Psychology Cognition Disorders Neuroscience Biomarkers |
| Zdroj: | Dementia and geriatric cognitive disorders. 28(1) |
| ISSN: | 1421-9824 |
| Popis: | Background/Aims: The aim of this study was to investigate the role of cerebrospinal fluid β-amyloid(1–42) levels and auditory event-related potentials (AERPs) in the progress of mild cognitive impairment (MCI) to Alzheimer’s disease (AD). Methods: In 53 MCI patients, lumbar puncture was performed and β-amyloid(1–42) levels were determined. Twenty patients were reexamined after 11 months. During this period, 5 of them progressed to AD. Neuropsychological and ERP analyses were performed on all patients during both baseline and endpoint examinations. Results: Compared to stable MCI patients, those that progressed to AD had significantly lower β-amyloid(1–42) levels (Mann-Whitney test, Z = –2.952, p = 0.003; effect size r = –0.41) and significantly prolonged N200 latencies (Mann-Whitney test, Z = –3.561, p < 0.001, effect size r = –0.49). From ERP variables, only the N200 latency significantly correlated with β-amyloid(1–42) levels (baseline examination: rs = –0.421, p = 0.002; follow-up examination: rs = –0.574, p = 0.008). Conclusions: The combined use of these two parameters enabled discrimination of stable MCI patients from those who developed AD, with 100% sensitivity and specificity. Therefore, this method could be of high diagnostic value for the early diagnosis of AD. |
| Databáze: | OpenAIRE |
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